Results 261 to 270 of about 60,497 (319)

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Nature Reviews Neuroscience, 2018
Junying Yuan, Palak Amin, D. Ofengeim
semanticscholar   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
The dual redox nature of polyphenols enables antioxidant activity and controlled reactive oxygen species (ROS) generation. This review details the biomedical applications of polyphenols in materials such as nanoparticles, coatings, and hydrogels for antimicrobial, tissue regeneration, and cancer therapies.
Jose Bolaños‐Cardet, Belén Pepió‐Tárrega, Javier Saiz‐Poseu, Alba López‐Moral, Faiz Ullah, Victor J. Yuste, Daniel Ruiz‐Molina, Salvio Suárez‐García   +7 more
wiley   +2 more sources

RIPK1 inhibition reduces biliary injury and fibrosis in primary sclerosing cholangitis. [PDF]

Sci Adv
Soret PA, Steunou V, Hedou J, Tokgozoglu J, Pistorio V, Majdi A, Darwane N, Delaunay JL, Benyahia S, Dinard L, Ledent T, Metatla I, Guerrera C, Lhomme M, Ponnaiah M, Galon J, Soussan P, Serfaty L, Corpechot C, Housset C, Aït-Slimane T, Verdonk F, Chazouillères O, Wendum D, Ratziu V, Lemoinne S, Cadoret A, Chignard N, Gautheron J.   +28 more
europepmc   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Trigger Points of Necroptosis (RIPK1, RIPK3, and MLKL)-Promising Horizon or Blind Alley in Therapy of Colorectal Cancer? [PDF]

Int J Mol Sci
Sokołowski M, Butrym A.
europepmc   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, Volume 59, Issue 2, February 2026.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis. [PDF]

J Inflamm Res
Lu J, Liang K, Zhang L, Cui B, You L, An R, Hu C, Wang X.   +7 more
europepmc   +1 more source

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

, 2016
et al,, Liapis, Helen
core   +2 more sources