Hyper-responsiveness to Stimulation of Human Immunodeficiency Virus-infected CD4+ T Cells Requires Nef and Tat Virus Gene Products and Results from Higher NFAT, NF-κB, and AP-1 Induction [PDF]
Journal of Biological Chemistry, 2004 A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the activation state of T cells indicate that both Nef and Tat can alter T cell activation.
Jean-François, Fortin +4 more
openaire +3 more sources
Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage
Retrovirology, 2009 Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent than in infected T cells.
Shah Sonia +3 more
doaj +2 more sources
Sensors, 2018 A Q-body capable of detecting target molecules in solutions could serve as a simple molecular detection tool. The position of the fluorescent dye in a Q-body affects sensitivity and therefore must be optimized.
Yoichi Kurumida, Nobuhiro Hayashi
doaj +2 more sources
Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy
Disease Models & Mechanisms, 2019 Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN ...
Rajni Vaid Puri +9 more
doaj +2 more sources
Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells [PDF]
, 2007 Background Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components.
Baschieri , Selene +7 more
core +3 more sources
Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product
Journal of General Virology, 1994 During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin +3 more
openaire +2 more sources
Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon [PDF]
, 2005 Simian immunodeficiency viruses (SIVcpz) infecting chimpanzees (Pan troglodytes) in west central Africa are the closest relatives to all major variants of human immunodeficiency virus type 1 ([HIV-1]; groups M, N and O), and have thus been implicated as ...
Ayouba, A +12 more
core +2 more sources
Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]
, 2011 Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan +4 more
core +1 more source
Memórias do Instituto Oswaldo Cruz, 2002 Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
M. L. Guimarães +2 more
semanticscholar +1 more source
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core +1 more source