Results 11 to 20 of about 12,704,228 (148)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein [PDF]

FEBS Open Bio, Volume 16, Issue 6, Page 1132-1141, June 2026.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +2 more sources

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]

, 2013
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO, PALU', GIORGIO, Qiu, Jianming, Smithgall, TE, Jerrod A Poe, J. A. Poe, Palumbo, M, Matteo Nadai, Ilaria Frasson, Poe, Jerrod A., Giorgio Palù, RICHTER, SARA, T. E. Smithgall, Poe, JA, Frasson Ilaria, Poe Jerrod A., Palù, Giorgio, Smithgall, Thomas E., Sara N Richter, Rosalba Perrone, Nadai, M, Palumbo Manlio, Richter, Sara N., Manlio Palumbo, Richter Sara N., Palù, G, Perrone, R, Richter, SN, Smithgall Thomas E., Palù Giorgio, Thomas E Smithgall, PERRONE, ROSALBA, Frasson, I, Nadai Matteo, FRASSON, ILARIA, PALUMBO, MANLIO, Perrone Rosalba   +36 more
core   +2 more sources

Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product

Journal of General Virology, 1994
During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin, M, Fauchon, A, Darveau, J A, Levy   +3 more
openaire   +2 more sources

Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells [PDF]

, 2007
Background Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components.
Buriani, Giampaolo, Nuttall, James, Marusic Carla, Lombardi Raffaele, Lombardi, Raffaele, Baschieri , Selene, Buriani Giampaolo, Eugenio Benvenuto, Lico Chiara, Baschieri Selene, Frigerio, Lorenzo, James Nuttall, Benvenuto Eugenio, Lorenzo Frigerio, Nuttall James, Giampaolo Buriani, Marusic, Carla, Selene Baschieri, Frigerio Lorenzo, Raffaele Lombardi, Benvenuto, Eugenio, Chiara Lico, Carla Marusic, Lico, Chiara   +23 more
core   +1 more source

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

Retrovirology, 2009
Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent than in infected T cells.
Shah Sonia, Kilareski Evelyn M, Nonnemacher Michael R, Wigdahl Brian   +3 more
doaj   +1 more source

Genetic diversity of Brazilian isolates of feline immunodeficiency virus [PDF]

, 2010
We isolated Feline immunodeficiency virus (FIV) from three adult domestic cats, originating from two open shelters in Brazil. Viruses were isolated from PBMC following co-cultivation with the feline T-lymphoblastoid cell line MYA-1.
HAGIWARA, M. K., Richtzenhain, L.J., CRUZ, J. C. M., HOSIE, M. J., REIS, J. K. P., Hagiwara, M.K., Cruz, J.C.M., WILLETT, B. J., Hosie, M.J., Logan, N., Willett, B.J., BRANDAO, P. E., Teixeira, Bruno Marques, Reis, J.K.P., Brandão, P.E., RICHTZENHAIN, L. J.   +15 more
core   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Disease Models & Mechanisms, 2019
Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN ...
Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma   +9 more
doaj   +1 more source

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation

Journal of General Virology, 1993
The human immunodeficiency virus (HIV) type 1 nef gene product was expressed as an N-terminal fusion protein with glutathione-S-transferase (GST) in the baculovirus system. The resulting nefGST fusion protein was found to be authentically myristylated at the N terminus and could be purified to homogeneity by one-step affinity chromatography on ...
M, Harris, K, Coates
openaire   +2 more sources

Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. [PDF]

, 1997
Published ...
Frances M. Gotch, Rusung Tan, Jim E. Stott, Kent, K, Stott, JE, Dong, Tao, Xiao-Ning Xu, Neil Almond, Richard Stebbings, Shigekazu Nagata, Almond, N, Tan, R, Gotch, FM, Nagata, S, Xu, XN, Barry Walker, Mcmichael, Andrew, Tao Dong, Andrew J. McMichael, Karen Kent, Dong, T, Stebbings, R, Gavin R. Screaton, Walker, B, Screaton, GR, McMichael, AJ   +25 more
core   +1 more source