Results 31 to 40 of about 41,389 (184)

Characterization of HIV‐1 Particles Co‐Purified With Three Extracellular Vesicle Subtypes From the Raji CD4 DCIR Cell Line, a Hybrid Model of CD4 T Cells and Dendritic Cells

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
The characterization of EVs and viruses co‐purified by differential centrifugation highlighted their diversity. The 3K pellet contained viruses with high infectivity, along with DAP‐3 and mitochondrial DNA enriched EVs. A lower infectivity was associated with the 17K pellet. The 17K EVs displayed ICAM‐1 and contained HSP70 and mitochondrial DNA.
Julien Boucher, Alyssa Rousseau, Caroline Gilbert   +2 more
wiley   +1 more source

Using death to one's advantage: HIV modulation of apoptosis [PDF]

, 2001
Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+ T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control of HIV replication and to the ...
A Algeciras, A Anel, A Badley, A Cafaro, A Greeway, A Kelekar, A Kinter, AD Osterhaus, AG Laurent-Crawford, AH Wyllie, AJ Darmon, AJ Minn, AL Van, AM Chinnaiyan, AS Baur, B Conradt, B Ensoli, BR Cullen, BR Gundlach, C Aiken, C Baumler, C Cicala, C Cicala, C Terai, CA Ray, CD Bortner, D Ho, D Reinhold, D Xue, D Zagury, D Zagury, DE Croal, DF Nixon, DiMarzio, DJ Li, DK Miller, DN Levy, DR Hodge, E Rapaport, EA Cohen, EB Stephens, EN Kraiselburd, ES Alnemri, ET Sawai, ET Sawai, F Cocchi, F Margottin, F Re, G Alkhatib, G Alkhatib, G Hacker, G Herbein, G Herbein, G Pan, G Zauli, GD Edwart, GL Stivahtis, H Choe, H Deng, H Okada, HL Robinson, I Agostini, I Szabo, J Bertin, J Dhein, J Estaquirer, J He, J Hesselgesser, J Hua, J Lama, J Savill, JBM Jowett, JC Ameisen, JC Ameisen, JC Reed, JE Rosok, JG Teodoro, JM Adams, JV Garcia, JW Balliet, K Ogawa, K Shasty, K Strebel, KA Jones, KL Collins, KM Murphy, KP Wilson, L Alexander, L Meyaard, L Selig, L Wang, L Zheng, LM Mansky, LT Quan, M Alderson, M Bouhamdan, M Ui, M Westendorp, MA Vodicka, MC Gauduin, MD Hazenberg, ME Rogel, MG Hengartner, MS Wyand, MX Wu, N Chirmule, N Hattori, NK Heinzinger, P Gallay, PA Sandstrom, PD Katsikis, PD Katsikis, PJ Maddon, R Antonasson, R Gehri, RA Black, RI Connor, RJ Clem, RP Viscidi, RT Allen, S Bour, S Hodge, S Mahalingam, S Schendel, S Sieg, S Wang, S-T Ju, SA Stewart, SF Purvis, SR Bartz, SR D'Mello, SS Cohen, T Brunner, TH Finkel, TM Ross, TM Ross, U Schubert, V Cryns, V Cryns, V Kolensnitchenko, W Paxton, WMS Guntheil, X Lu, X-J Yao, X-N Xu, Y Collette, Y Hu, YBC Feng, YL Lu, Z Wang   +149 more
core   +1 more source

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

MedComm, Volume 6, Issue 11, November 2025.
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin, Lingxiang Xie, Hongqi Zhang, Xiang Fan, Jiaxing Tian, Wei Liu, Yang Xiao, Xinrong Fan   +7 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions. [PDF]

, 2013
Background: Live attenuated SIV induces potent protection against superinfection with virulent virus; however the mechanism of this vaccine effect is poorly understood.
Almond, N, Berkhout, B, Berry, N, Cranage, MP, Das, AT, Ferguson, D, Ham, C, Li, B, Manoussaka, MS, Page, M, Robinson, M, Stebbings, R   +11 more
core   +2 more sources

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

HIV‐1 viral protein effect on cerebral microvasculature: An in vitro blood–brain barrier model

Physiological Reports, Volume 13, Issue 19, October 2025.
Abstract The central nervous system (CNS) serves as a sanctuary for the Human Immunodeficiency Virus (HIV), which is facilitated by HIV's ability to breach the blood–brain barrier (BBB). BBB dysfunction occurs in the earliest stages of an HIV‐1 infection.
Sinelisiwe Matubatuba, Chontrelle Willemse, Khayelihle Brian Makhathini, Carine Smith, David Fisher, Shireen Mentor   +5 more
wiley   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, Volume 5, Issue 9, September 2025.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source