Results 51 to 60 of about 41,389 (184)

The Peptide PROTAC Modality: A New Strategy for Drug Discovery

MedComm, Volume 6, Issue 4, April 2025.
Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley   +1 more source

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors. [PDF]

, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
A Alcami, A Alcami, A Harari, A Harari, A Subramanian, Abdelali Filali-Mouhim, AD Bins, AJ McNeil, Alexandre Harari, Anke Redeker, Antonio Lanzavecchia, B Perdiguero, Beatriz Perdiguero, Bertram L. Jacobs, Carmen E. Gomez, CE Gomez, CE Gomez, CE Gomez, CF Ockenhouse, CJM Melief, Clive Gray, Cornelis J. M. Melief, D Chaussabel, D Gaucher, David M. Koelle, DD Richman, DH O'Connor, DR Burton, E Paoletti, E Tryniszewska, Elias K. Haddad, Esther D. Quakkelaar, Federica Sallusto, Ferry Ossendorp, G Sutter, Giuseppe Pantaleo, GK Smith, J Tartaglia, J Tartaglia, JA Espmark, JA Symons, Jean-Philippe Goulet, Jim Tartaglia, JL Najera, JL Najera, Karen V. Kibler, L Jing, L Jing, LJ Sigal, M Carrington, M Esteban, M Terajima, Mariano Esteban, ME Perkus, ME Perkus, MJ Kuroda, MP Longhi, N Frahm, N Frahm, N Oguiura, N Romani, N van Montfoort, NA Wilson, Nikki M. Loof, OR Colamonici, P Mooij, P Mooij, PA Bart, Paul Heinen, RA Koup, Rafick P. Sékaly, RN Van Gelder, RP Sekaly, S Guerra, S McCormack, S Rerks-Ngarm, SA Migueles, SS Jackson, Stella Mayo McCaughey, Thomas Duhen, X Shen, X Wei, Y Benjamini, Z Hel, Z Hel   +84 more
core   +4 more sources

Grb3-3 Is Up-regulated in HIV-1-infected T-cells and Can Potentiate Cell Activation through NFATc*

Journal of Biological Chemistry, 2000
The MAPK pathway is required for T-cell activation; however, its role in modulating T-cell function following human immunodeficiency virus type 1 (HIV-1) infection is poorly understood.
X. Li, M. Multon, Y. Hénin, F. Schweighoffer, C. Venot, J. Josef, C. Zhou, J. Lavecchio, P. Stuckert, M. Raab, A. Mhashilkar, B. Tocqué, W. Marasco   +12 more
semanticscholar   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [PDF]

, 2019
BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms
Aran, Dvir, Butte, Atul J, Greene, Warner C, Hsieh, Christine, Joshi, Sunil, Kim, Peggy, Montano, Mauricio, Morón-López, Sara, Telwatte, Sushama, Wong, Joseph K, Yukl, Steven A   +10 more
core   +1 more source

Antigen presentation of post‐translationally modified peptides in major histocompatibility complexes

Immunology &Cell Biology, Volume 103, Issue 2, Page 161-177, February 2025.
T cells recognize pathogens and malignantly transformed cells through antigen presentation on major histocompatibility complex molecules. Post‐translational modifications (PTMs) of proteins can alter the peptides presented, influencing immune recognition and disease.
Alexine S de Wit, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin [PDF]

, 1996
Since 1989, human immunodeficiency virus type 1 (HIV-1) has spread explosively through the heterosexual population in Thailand. This epidemic is caused primarily by viruses classified as "subtype E", which, on the basis of limited sequence comparisons ...
Craig, S, Decker, J, Fultz, P N, Gao, F, Girard, M, Hahn, B H, Hui, H X, Morrison, S G, Robertson, D L, Sharp, P M, Shaw, G M   +10 more
core   +1 more source

Acute-Phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus [PDF]

, 2013
The overall CD8 T cell response to human/simian immunodeficiency virus (HIV/SIV) targets a collection of discrete epitope specificities. Some of these epitope-specific CD8 T cells emerge in the weeks and months following infection and rapidly select ...
Becker, E., Braasch, A., Broman, K., Burns, C., Friedrich, T., Gostick, Emma, Harris, M., Johnson, R., O'Connor, S., Price, David   +9 more
core   +1 more source

The Interplay Between Viral Infection and Cell Death: A Ping‐Pong Effect

Advances in Virology, Volume 2025, Issue 1, 2025.
Programmed cell death (PCD) is a well‐studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival.
Alireza Nourazarian, Hadi Yousefi, Cigir Biray Avci, Behrouz Shademan, Emad Behboudi, Ahmed Majeed Al-Shammari   +5 more
wiley   +1 more source

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models [PDF]

, 2016
To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed.
Bonczkowski, Pawel, Borch, Alexandra, De Scheerder, Marie-Angélique, De Spiegelaere, Ward, Koenig, Renate, Malatinková, Eva, Melkova, Zora, Vandekerckhove, Linos   +7 more
core   +1 more source