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The Confluence of HIV‐1 and HIV‐2: Implications for Disease Progression and Insights for Therapy
International Journal of Microbiology, Volume 2025, Issue 1, 2025.Two distinct types of human immunodeficiency virus (HIV), namely, HIV‐1 and HIV‐2 exist. HIV‐1 is responsible for the global pandemic and has an aggressive pathogenesis. On the contrary, HIV‐2 is not only less aggressive but also confined to West and Central African regions.
Edwin Magomere +7 more
wiley +1 more source
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. [PDF]
, 2015 BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins.
Ciuffi, A. +16 more
core +2 more sources
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection [PDF]
, 2018 Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals infected with HIV-1. It has long been known that HIV-1 infection alters the course of M.
Bell, LCK, Noursadeghi, M
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HIV-1 Neutralisation and Other Aspects of the Envelope Glycoprotein
, 2009 The absence of an effective humoral response contributes to the failure of controlling HIV-1 infection. Methods to elicit a potent neutralising antibody response is still underway and this thesis explores three aspects that can affect neutralisation. The
Lai, Pei-Jen, Lai, Pei-Jen
core +1 more source
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. [PDF]
, 2018 Unbiased shRNA library screens revealed that the estrogen receptor-1 (ESR-1) is a key factor regulating HIV-1 latency. In both Jurkat T cells and a Th17 primary cell model for HIV-1 latency, selective estrogen receptor modulators (SERMs, i.e ...
Bacchetti, Peter +11 more
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In vitro selection and characterisation of human anti-HIV-1 antibody fragments [PDF]
, 2011 Generation of neutralising antibodies with broad specificity would be one of the effective approaches to control HIV-1 spread. It is clear that a method that allows rapid generation of neutralising antibodies is needed.
Tang, J., Tang, J.
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ZNRD1 (Zinc Ribbon Domain-Containing 1) Is a Host Cellular Factor That Influences HIV-1 Replication and Disease Progression [PDF]
, 2017 Background Human immunodeficiency virus (HIV) takes advantage of multiple host proteins to support its own replication. The gene ZNRD1 (zinc ribbon domain-containing 1) has been identified as encoding a potential host factor that influenced disease ...
Ballana, Ester +13 more
core