Results 71 to 80 of about 15,184 (223)

Bile Acid Binding Resins Improve Glucagon Receptor Agonist‐Mediated Weight Loss in Diet‐Induced Obese Mice

Obesity, Volume 34, Issue 2, Page 428-438, February 2026.
ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim, Mackenzie J. Pearson, Huixian Hong, Shelly Nason, Khadija Seck, Jessica Antipenko, Natalie Presedo, Richard DiMarchi, William C. Roell, Kirk Habegger   +9 more
wiley   +1 more source

Effect of high NEFA concentration on lipid metabolism disorders in hepatocytes based on lipidomics

Frontiers in Pharmacology
Introduction: High concentrations of nonesterified fatty acids (NEFA) is the key of characteristic of fatty liver in dairy cows. Therefore, the aim of this study was to investigate the effect of high concentration of NEFA on lipid metabolism in ...
Xinyi Fan, Jie Xu, Yuan Hu, Kui Wang, Yiyi Zhao, Jinyin Cai, Xinyuan Zhang, Binghai Pan, Anqi Xu, Yajing Chen, Songhao Liu, Kangfeng Jiang, Xiaobing Li   +12 more
doaj   +1 more source

Contribution of glycerophospholipids and sphingomyelin to the circulating NEFA

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016
Serum nonesterified fatty acids (NEFA) are known to be associated with the development of insulin resistance. Recently, differences in the NEFA profile were found in subjects with history of gestational diabetes (postGDM) and healthy controls. Little is known about the NEFA sources in the postprandial state, which prevails most of the day in humans in ...
Felicitas Maier, Hans Demmelmair, Marina Fugmann, Christian Hellmuth, Andreas Lechner, Berthold Koletzko, Olaf Uhl   +6 more
openaire   +4 more sources

Gpx4 Deletion‐Mediated Macrophage Ferroptosis Alleviates Obesity‐Associated Insulin Resistance

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Macrophage‐specific loss of Gpx4 induces ferroptosis, thereby alleviating high‐fat diet (HFD)‐induced obesity, insulin resistance, and metabolic dysfunction, and conferring systemic metabolic protection in type 2 diabetes (T2D). ABSTRACT Obesity has become a global epidemic and a major contributor to the development of Type 2 diabetes (T2D) through the
Suhua Wu, Juan Peng, Xiaodong Wang, Hong Gao, Huangrui Fang, Shiyi Hu, Qiufen Wei, Yuanye Dang, Haixia Tu, Mingyan Zhu, Jianye Peng, Yumiao Liu, Gaofeng Zeng, Xiaoyan Dai   +13 more
wiley   +1 more source

Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose

Journal of Lipid Research, 1999
The integration of lipid metabolism in the splanchnic bed and in subcutaneous adipose tissue before and after ingestion of a 75 g glucose load was studied by Fick's principle in seven healthy subjects.
Jens Bülow, Lene Simonsen, David Wiggins, Sandy M. Humphreys, Keith N. Frayn, David Powell, Geoffrey F. Gibbons   +6 more
doaj   +1 more source

Proximal Tubule‐Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Daiki Aomura, Takayuki Nimura, Kosuke Yamaka, Yosuke Yamada, Makoto Harada, Takero Nakajima, Takefumi Kimura, Koji Hashimoto, Hiroyuki Kanno, Motoko Yanagita, Frank J. Gonzalez, Naoki Tanaka, Yuji Kamijo   +12 more
wiley   +1 more source

Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy

Journal of Dairy Science
: High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress.
Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J. Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li   +16 more
doaj   +1 more source

Pengetahuan Persepsi dan Partisipasi Masyarakat dalam Pemanfaatan Ruang Berwawasan Lingkungan di Kota Bengkulu

Majalah Geografi Indonesia, 2016
ABSTRAK Kebutuhan pemanfaatan ruang di wilayah Kota Bengkulu terus meningkat sejalan dengan meningkatnya aktifitas masyarakat dan kegiatan sosial ekonomi yang menyertainya.
Nefa Yulia, Suratman Suratman, Su Ritohardoyo   +2 more
doaj   +1 more source

Caveolin 1 ameliorates nonesterified fatty acid–induced oxidative stress via the autophagy regulator beclin 1 in bovine mammary gland epithelial cells

Journal of Dairy Science
: High blood concentrations of nonesterified fatty acids (NEFA) during ketosis enhance uptake by the mammary gland and impair autophagy while causing oxidative stress.
Kai Liu, Yifei Dong, Liguang Cao, Guojin Li, Zifeng Yang, Jianchun Luo, Lin Lei, Xiliang Du, Yuxiang Song, Muhammad Usman, Juan J. Loor, Guowen Liu, Xinwei Li, Wenwen Gao   +13 more
doaj   +1 more source

Effects of Hormone, NEFA and SCFA on the Migration of Neutrophils and the Formation of Neutrophil Extracellular Traps in Dairy Cows [PDF]

, 2022
Guanxin Lv, Hai Wang, Xiechen Zhou, Shuai Lian, Jianfa Wang, Rui Wu   +5 more
openalex   +1 more source