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Physiological regulation of NEFA availability: lipolysis pathway [PDF]
Proceedings of the Nutrition Society, 2004 Plasma NEFA are an important energy substrate and, furthermore, play a key role in the induction of insulin resistance in the body. The availability of NEFA is determined predominantly by their mobilization from adipose tissue triacylglycerol stores by the process of lipolysis.
V, Stich, M, Berlan
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Scientific Reports, 2022 Obesity is a complex disease that increases an individual’s risk of developing other diseases and health-related problems. A common feature is dyslipidemia characterized by increased levels of plasma lipids, which include non-esterified fatty acids ...
Stephen J. Hierons +6 more
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Are we waking up to the effects of NEFA? [PDF]
Diabetologia, 2015 NEFA are mobilised from adipose tissues during fasting or stress. Under conditions of acute or chronic NEFA excess, skeletal muscle and hepatic insulin resistance may ensue. Hence, a wealth of literature has focused on the crosstalk between NEFA and glucose in the pathogenesis of insulin resistance.
Jonathan C, Jun, Vsevolod Y, Polotsky
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Frontiers in Cell and Developmental Biology, 2019 Non-esterified fatty acids (NEFAs) promote de novo lipogenesis, which caused abnormal hepatic lipid accumulation, by the NFκB–Orai1 pathway. Oxidative stress and endoplasmic reticulum (ER) stress have been recognized as key mechanisms in non-alcoholic ...
Bingbing Zhang +8 more
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Metabolites, 2023 Maternal obesity and gestational diabetes mellitus (GDM) are linked with impaired placental function and early onset of non-communicable cardiometabolic diseases in offspring. Previous studies have highlighted that the dietary non-esterified fatty acids (
Zachary J. W. Easton +7 more
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Contribution of glycerophospholipids and sphingomyelin to the circulating NEFA
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016 Serum nonesterified fatty acids (NEFA) are known to be associated with the development of insulin resistance. Recently, differences in the NEFA profile were found in subjects with history of gestational diabetes (postGDM) and healthy controls. Little is known about the NEFA sources in the postprandial state, which prevails most of the day in humans in ...
Felicitas Maier +6 more
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Cellular Physiology and Biochemistry, 2015 Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity.
Wiebke Gehrmann +5 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies ...
Neil K. Huang +8 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Dairy cows with clinical ketosis display a negative energy balance and high blood concentrations of non-esterified fatty acids (NEFAs), the latter of which is an important pathological factor of ketosis in cows.
Yuming Zhang +7 more
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Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats. [PDF]
PLoS ONE, 2013 This study tested whether the glycogen-accumulating effect of chronic in vivo pharmacological 5'AMP-activated protein kinase (AMPK) activation could improve glycemic control under conditions of insulin deficiency.
Kaio F Vitzel +6 more
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