Results 31 to 40 of about 4,852 (215)

Are we waking up to the effects of NEFA? [PDF]

Diabetologia, 2015
NEFA are mobilised from adipose tissues during fasting or stress. Under conditions of acute or chronic NEFA excess, skeletal muscle and hepatic insulin resistance may ensue. Hence, a wealth of literature has focused on the crosstalk between NEFA and glucose in the pathogenesis of insulin resistance.
Jonathan C, Jun, Vsevolod Y, Polotsky
openaire   +2 more sources

NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease

Frontiers in Cell and Developmental Biology, 2019
Non-esterified fatty acids (NEFAs) promote de novo lipogenesis, which caused abnormal hepatic lipid accumulation, by the NFκB–Orai1 pathway. Oxidative stress and endoplasmic reticulum (ER) stress have been recognized as key mechanisms in non-alcoholic ...
Bingbing Zhang, Ming Li, Ying Zou, Han Guo, Bingdong Zhang, Cheng Xia, Hongyou Zhang, Wei Yang, Chuang Xu   +8 more
doaj   +1 more source

Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies ...
Neil K. Huang, Petra Bůžková, Nirupa R. Matthan, Luc Djoussé, Calvin H. Hirsch, Jorge R. Kizer, W. T. Longstreth, Kenneth J. Mukamal, Alice H. Lichtenstein   +8 more
doaj   +1 more source

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity.
Wiebke Gehrmann, Wiebke Würdemann, Thomas Plötz, Anne Jörns, Sigurd Lenzen, Matthias Elsner   +5 more
doaj   +1 more source

Contribution of glycerophospholipids and sphingomyelin to the circulating NEFA

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016
Serum nonesterified fatty acids (NEFA) are known to be associated with the development of insulin resistance. Recently, differences in the NEFA profile were found in subjects with history of gestational diabetes (postGDM) and healthy controls. Little is known about the NEFA sources in the postprandial state, which prevails most of the day in humans in ...
Felicitas Maier, Hans Demmelmair, Marina Fugmann, Christian Hellmuth, Andreas Lechner, Berthold Koletzko, Olaf Uhl   +6 more
openaire   +4 more sources

Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows

Cellular Physiology and Biochemistry, 2018
Background/Aims: Dairy cows with clinical ketosis display a negative energy balance and high blood concentrations of non-esterified fatty acids (NEFAs), the latter of which is an important pathological factor of ketosis in cows.
Yuming Zhang, Xiaobing Li, Haolong Zhang, Zhibo Zhao, Zhicheng Peng, Zhe Wang, Guowen Liu, Xinwei Li   +7 more
doaj   +1 more source

Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats. [PDF]

PLoS ONE, 2013
This study tested whether the glycogen-accumulating effect of chronic in vivo pharmacological 5'AMP-activated protein kinase (AMPK) activation could improve glycemic control under conditions of insulin deficiency.
Kaio F Vitzel, George Bikopoulos, Steven Hung, Kathryn E Pistor, Jessica D Patterson, Rui Curi, Rolando B Ceddia   +6 more
doaj   +1 more source

La representación de Héctor en Troyanas de Séneca: el primer nefas [PDF]

, 2013
En la presente comunicación nos centraremos en el análisis de la imagen de Héctor en Troyanas de Séneca. Hemos observado que con ella los personajes definen y describen situaciones.
Pedernera, Soledad
core   +1 more source

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids[S]

Journal of Lipid Research, 2017
Lipid accumulation is a pathological feature of every type of kidney injury. Despite this striking histological feature, physiological accumulation of lipids in the kidney is poorly understood.
Diego Scerbo, Ni-Huiping Son, Alaa Sirwi, Lixia Zeng, Kelli M. Sas, Vincenza Cifarelli, Gabriele Schoiswohl, Lesley-Ann Huggins, Namrata Gumaste, Yunying Hu, Subramaniam Pennathur, Nada A. Abumrad, Erin E. Kershaw, M. Mahmood Hussain, Katalin Susztak, Ira J. Goldberg   +15 more
doaj   +1 more source

Subsidiarity Principle—Its Realization in Self-Government in Lithuania and Poland

Administrative Sciences, 2020
Purpose: This paper analyzes the development of the concept of subsidiarity, its relationship with management theories and the implementation of the principle of subsidiarity in the context of local self-government in Poland and Lithuania by conducting ...
Robert Gawłowski, Saulius Nefas, Krzysztof Makowski   +2 more
doaj   +1 more source