Results 51 to 60 of about 3,674 (185)

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

Influence of endogenous NEFA on beta cell function in humans [PDF]

Diabetologia, 2015
It is a commonly held view that chronically elevated NEFA levels adversely affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta cell function has only been explored using acute NEFA elevations. Our aim was to analyse the relationship between endogenous NEFA levels and beta cell function.In 1,267 individuals ...
Rebelos, Eleni, Seghieri, Marta, NATALI, ANDREA, Balkau, Beverly, Golay, Alain, Piatti, Pier Marco, Lalic, Nebojsa M., Laakso, Markku, Mari, Andrea, Ferrannini, Ele   +9 more
openaire   +5 more sources

Impact of Heated Versus Unheated Cooking Oil on Postprandial Vascular Function and Metabolism

Lipids, EarlyView.
ABSTRACT The impact of repeated heating of seed‐based culinary oils on cardiometabolic health has not been well established. Heating oils to high temperatures (> 150°C) causes lipid peroxidation, thus generating potentially harmful compounds that may impair vascular function. This randomized, single‐blind, crossover study investigated the acute effects
Rosiered Brownson‐Smith, Jo Bruce, Esmat Abbas, Sarah Fissler, Wendy Hall, Sarah Berry   +5 more
wiley   +1 more source

Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows

Metabolites, 2022
Early successful conception of postpartum dairy cows is crucial in determining the optimum reproductive efficiency and profitability in modern dairy farming.
Abdul Sammad, Muhammad Zahoor Khan, Zaheer Abbas, Lirong Hu, Qudrat Ullah, Yajing Wang, Huabin Zhu, Yachun Wang   +7 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Plasma Metabolomic Analysis Reveals the Relationship between Immune Function and Metabolic Changes in Holstein Peripartum Dairy Cows

Metabolites, 2022
Dairy cows undergo dynamic physiological changes from late gestation to early lactation, including metabolic changes and immune dysfunction. The aim of this study was to investigate the relationship between immune function and metabolic changes in ...
Zhuo Yang, Fang Luo, Guolin Liu, Zhengzhong Luo, Sijia Ma, Hang Gao, Hailong He, Jinzhong Tao   +7 more
doaj   +1 more source

Absence of Interaction Between 5α‐Reductase Inhibitors and Glucocorticoids on Incidence of Myocardial Infarction in People With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims People with Type 2 diabetes experience higher cardiometabolic risk, and both synthetic glucocorticoids and use of 5α‐reductase inhibitors have been individually linked to increased risk of myocardial infarction. We tested whether the increase in risk is exacerbated by co‐prescription of both drugs.
Haolan Tu, Chengsheng Ju, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Scottish Diabetes Research Network Epidemiology Group, Peter Hanlon, Robert Lindsay, David McAllister, John Petrie, Naveed Sattar, Brian Kennon, Sam Philip, Scott Cunningham, Huan Wang, William Berthon, Helen Colhoun, Paul McKeigue, Sarah Wild, Ewan R. Pearson, Li Wei, Ruth Andrew   +20 more
wiley   +1 more source

Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile

Animals, 2021
This study aimed to evaluate the possible relationship among UCP1, body weight, rectal temperature and lipid profile in the horse. Thirty clinically healthy Italian Saddle geldings (6–10 years old) were enrolled after the informed owners’ consent.
Francesca Arfuso, Claudia Giannetto, Maria Francesca Panzera, Francesco Fazio, Giuseppe Piccione   +4 more
doaj   +1 more source

Diet‐Related Differences Predominate Over Breed‐Associated Differences in Hepatic Lipid Metabolism, Antioxidant Vitamins and Lipid Quality Indices Among Beef Cattle

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Understanding how nutritional management and genetic background influence hepatic metabolism is important for improving the nutritional quality of bovine products in tropical production systems. This study evaluated breed‐associated differences under a common dietary regimen and diet‐related differences within the Nelore breed with respect to ...
Laíza de Kássia Mendes da Conceição, José de Brito Lourenço‐Júnior, Jamile Andréa Rodrigues da Silva, Leonel António Joaquim, Mariana Jucá Moraes, Thomaz Cyro Guimarães de Carvalho Rodrigues, Joana Inês Ferreira, Ana Maria Ramos Fontes, Maria Pinheiro Spínola, Érica Coutinho David, Antônio Vinicius Correa Barbosa, Bruno Cabral Soares, José António Mestre Prates   +12 more
wiley   +1 more source

Comparative Analysis of Lipids and Fatty Acids in Beaked Redfish Sebastes mentella Travin, 1951 Collected in Wild and in Commercial Products

Journal of Marine Science and Engineering, 2022
The lipid and fatty acid profile of muscles in beaked redfish, caught and fixed in the wild versus specimens from food supermarkets (“commercial”), were evaluated, as well as the health implications of this popular food for its consumers based on the ...
Svetlana A. Murzina, Viktor P. Voronin, Tatjana R. Ruokolainen, Dmitrii V. Artemenkov, Alexei M. Orlov   +4 more
doaj   +1 more source