Results 51 to 60 of about 4,852 (215)

Influence of endogenous NEFA on beta cell function in humans [PDF]

Diabetologia, 2015
It is a commonly held view that chronically elevated NEFA levels adversely affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta cell function has only been explored using acute NEFA elevations. Our aim was to analyse the relationship between endogenous NEFA levels and beta cell function.In 1,267 individuals ...
Rebelos, Eleni, Seghieri, Marta, NATALI, ANDREA, Balkau, Beverly, Golay, Alain, Piatti, Pier Marco, Lalic, Nebojsa M., Laakso, Markku, Mari, Andrea, Ferrannini, Ele   +9 more
openaire   +5 more sources

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

From bodyweight to biomarkers: Season‐associated metabolic, endocrine and haematological shifts in breeding stallions

Equine Veterinary Journal, EarlyView.
Abstract Background Breeding stallions are subjected to sustained seasonal metabolic, endocrine, and immune demands requiring systemic energy engagement. Prospective longitudinal data in the same individuals are limited. Objectives To screen adaptive responses of breeding stallions of clinical relevance through longitudinal characterisation of temporal
Maria Grazia Cappai, Morrone Sarah, Senes Alice, Taras Andrea, Biggio Giampaolo, Cherchi Raffaele   +5 more
wiley   +1 more source

Plasma Metabolomic Analysis Reveals the Relationship between Immune Function and Metabolic Changes in Holstein Peripartum Dairy Cows

Metabolites, 2022
Dairy cows undergo dynamic physiological changes from late gestation to early lactation, including metabolic changes and immune dysfunction. The aim of this study was to investigate the relationship between immune function and metabolic changes in ...
Zhuo Yang, Fang Luo, Guolin Liu, Zhengzhong Luo, Sijia Ma, Hang Gao, Hailong He, Jinzhong Tao   +7 more
doaj   +1 more source

Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows

Metabolites, 2022
Early successful conception of postpartum dairy cows is crucial in determining the optimum reproductive efficiency and profitability in modern dairy farming.
Abdul Sammad, Muhammad Zahoor Khan, Zaheer Abbas, Lirong Hu, Qudrat Ullah, Yajing Wang, Huabin Zhu, Yachun Wang   +7 more
doaj   +1 more source

Multi‐omics reveals gastrointestinal metabolic disorder‐induced diarrhea in postpartum dairy cows

iMetaOmics, EarlyView.
Nutritional diarrhea is a pervasive, costly challenge in dairy production. Using integrated metagenomic and metabolomic profiling, we identified coordinated microbial and metabolic alterations across the rumen, hindgut, and serum. In the rumen, enrichment of Prevotella sp.
Weixuan Tang, Yangyi Hao, Jiawei Zhang, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li   +7 more
wiley   +1 more source

Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile

Animals, 2021
This study aimed to evaluate the possible relationship among UCP1, body weight, rectal temperature and lipid profile in the horse. Thirty clinically healthy Italian Saddle geldings (6–10 years old) were enrolled after the informed owners’ consent.
Francesca Arfuso, Claudia Giannetto, Maria Francesca Panzera, Francesco Fazio, Giuseppe Piccione   +4 more
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Nefas! L'iter di una interiezione tra generi e modelli letterari

, 2020
Il lavoro dimostra come il termine nefas sia stato utilizzato in età imperiale dai poeti per esprimere le loro emozioni e come tale uso sia ripreso da uno storico particolare, come ...
Chiara Renda
core  

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source