Results 21 to 30 of about 4,359 (219)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia

Scientific Reports, 2021
COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established.
Maxime Nguyen, Abderrahmane Bourredjem, Lionel Piroth, Bélaïd Bouhemad, Antoine Jalil, Gaetan Pallot, Naig Le Guern, Charles Thomas, Thomas Pilot, Victoria Bergas, Hélène Choubley, Jean-Pierre Quenot, Pierre-Emmanuel Charles, Laurent Lagrost, Valerie Deckert, Jean-Paul Pais de Barros, Pierre-Grégoire Guinot, David Masson, Christine Binquet, Thomas Gautier, Mathieu Blot, Lymphonie study group   +21 more
doaj   +1 more source

Non-esterified fatty acids and telomere length in older adults: The Cardiovascular Health Study

Metabolism Open, 2020
Background: Telomeres shorten as organisms age, placing limits on cell proliferation and serving as a marker of biological aging. Non-esterified fatty acids (NEFAs) are a key mediator of age-related metabolic abnormalities. We aimed to determine if NEFAs
Peter Ahiawodzi, Annette L. Fitzpatrick, Luc Djousse, Joachim H. Ix, Jorge R. Kizer, Kenneth J. Mukamal   +5 more
doaj   +1 more source

Non-esterified fatty acids generate distinct low-molecular weight amyloid-β (Aβ42) oligomers along pathway different from fibril formation. [PDF]

PLoS ONE, 2011
Amyloid-β (Aβ) peptide aggregation is known to play a central role in the etiology of Alzheimer's disease (AD). Among various aggregates, low-molecular weight soluble oligomers of Aβ are increasingly believed to be the primary neurotoxic agents ...
Amit Kumar, Rebekah L Bullard, Pritesh Patel, Lea C Paslay, Dipti Singh, Ewa A Bienkiewicz, Sarah E Morgan, Vijayaraghavan Rangachari   +7 more
doaj   +1 more source

Nefas

, 1987
SINI, Francesco
core   +2 more sources

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ [PDF]

Diabetologia, 2018
The blood triacylglycerol level is one of the main determinants of blood Mg2+ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg2+ concentration 27 kg/m2) who participated in the 300-Obesity study (an observational cross-sectional cohort study, as part of the Human Functional Genetics Projects), we investigated the association
Kurstjens, S, de Baaij, JHF, Overmars-Bos, C, Van Den Munckhof, ICL, Garzero, V, De Vries, MA, Burggraaf, B, Van Diepen, JA, Riksen, NP, Rutten, JHW, Netea, MG, Cabezas, M, Bindels, RJM, Ashcroft, FM, Tack, CJJ, Hoenderop, JGJ   +15 more
openaire   +4 more sources

Systemic redox status in lung cancer patients is related to altered glucose metabolism. [PDF]

PLoS ONE, 2018
Altered systemic redox status is often observed in lung cancer. However, detailed information on factors other, than smoking, which influence this perturbation is rather scarce.
Katarzyna Zabłocka-Słowińska, Sylwia Płaczkowska, Anna Prescha, Konrad Pawełczyk, Monika Kosacka, Irena Porębska, Halina Grajeta   +6 more
doaj   +1 more source

Serum Nonesterified Fatty Acids and Incident Stroke: The CHS

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies.
Neil K. Huang, Mary L. Biggs, Nirupa R. Matthan, Luc Djoussé, W. T. Longstreth, Kenneth J. Mukamal, David S. Siscovick, Alice H. Lichtenstein   +7 more
doaj   +1 more source

Narrative Nefas and the Taboos of Incest and Bestiality in Ovid’s Metamorphoses [PDF]

, 2022
This thesis explores the taboos on incest and bestiality, as they are presented in Ovid’s Metamorphoses, from a psychoanalytic and narratological perspective, through the lens of nefas (‘unspeakability’).
WATSON, JOSEPH,LAWRENCE
core  

Serum nonesterified fatty acids have utility as dietary biomarkers of fat intake from fish, fish oil, and dairy in women[S]

Journal of Lipid Research, 2020
Nutritional studies rely on various biological specimens for FA determination, yet it is unclear how levels of serum NEFAs correlate with other circulating lipid pools. Here, we used a high-throughput method (
Sandi M. Azab, Russell J. de Souza, Koon K. Teo, Sonia S. Anand, Natalie C. Williams, Jordan Holzschuher, Chris McGlory, Stuart M. Philips, Philip Britz-McKibbin   +8 more
doaj   +1 more source