Results 171 to 180 of about 2,682,293 (230)

Metabolism Controls the Timing of Human Brain Development and Maturation. [PDF]

J Inherit Metab Dis
Rava V, Cannone E, Francolini M, Taverna E.   +3 more
europepmc   +1 more source

2D U‐Net Framework for Multiclass Automated Segmentation of Healthy Structures, Ischemic Stroke, and Glioblastoma in the Rat Brain

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
A multitask 2D U‐Net framework enabling automated, accurate segmentation and quantification of rodent brain regions, stroke lesions, and tumors from MRI data. ABSTRACT Rodents are essential for preclinical brain disease research, including stroke, tumors, and neurodegenerative disorders.
Sara Ortega‐Espina, Sabela Fernández‐Rodicio, María Luz Alonso‐Alonso, Pelayo García‐Acevedo, Ana Sampedro‐Viana, Marcos Bazarra‐Barreiros, María Teresa Abengoza‐Bello, Antonio J. Mosqueira, Jacobo Porto‐Álvarez, Javier Martínez Fernández, Crhistian‐Mario Oblitas, José Castillo, Pablo Hervella, Ramón Iglesias‐Rey   +13 more
wiley   +1 more source

Shaping the Neocortex: Radial Glia and Astrocytes in Development and Evolution. [PDF]

J Neurosci
Mosti F, Kawasaki H, Babbit C, di Benedetto B, Silver DL, Kalebic N, Falcone C.   +6 more
europepmc   +1 more source

Push–pull hypothesis of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract The “push–pull” hypothesis of Alzheimer's disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia, promoting the collapse of proteostasis, reducing tau degradation, and facilitating the cell‐to ...
Matthew Townsend
wiley   +1 more source

Calretinin and Parvalbumin Trapping of TDP43 and XRCC1 Instructs Neocortical Interneuron Death in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

Biomolecules
Martin LJ, Ichord RN, O'Brien CE, Yohannan S, Fernandez D, Garrido A, Amauri N, Park D, Benderoth J, Lee JK.   +9 more
europepmc   +1 more source

The shared genetic architecture of the TDP‐43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION TAR DNA‐binding protein 43 (TDP‐43) proteinopathies encompass a spectrum of conditions including frontotemporal lobar degeneration with TDP‐43 inclusions (FTLD‐TDP), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE‐NC), and hippocampal sclerosis (HS).
Maulikkumar Patel, Pawan Kumar, Daniel Western, Matthew Johnson, Menghan Liu, John Budde, Carlos Cruchaga, Cyril Pottier   +7 more
wiley   +1 more source

Age‐linked biological context shapes adaptive immunity in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract Alzheimer's disease (AD) is increasingly recognized as a neuroimmune disorder with protective or pathogenic adaptive immunity dependent on the biological context. This review synthesizes evidence from human studies, genetic analyses, mouse models, and clinical trials to examine how lymphocytes and humoral immunity influence AD.
Sophie Shirenova, Arya Biragyn, Eitan Okun   +2 more
wiley   +1 more source

Adaptive evolution of gene regulatory networks in mammalian neocortex. [PDF]

Nature
Li Z, Kaur N, Santpere G, Muchnik SK, Sindhu SK, Qi C, Shibata M, Clément O, Klarić TS, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi SH, Kim H, Tebbenkamp ATN, Ma S, Han W, Kim SK, Pochareddy S, Duy PQ, Xing X, Bao Y, Xu X, Gladwyn-Ng IE, Cullen HD, Paolino A, Fenlon LR, Kozulin P, Suárez R, Risgaard RD, Gulden FO, Karger A, Suzuki IK, Hirata T, Gobeske KT, Richards LJ, Sousa AMM, Heng JI, Sestan N.   +40 more
europepmc   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Mixed Signals and Interspecies Variation in the Plasticity of Adult Mammal Brains. [PDF]

Cells
Pattaro A, Ghibaudi M, Zanone A, Cerrato V, Sherwood CC, Bonfanti L.   +5 more
europepmc   +1 more source