Results 191 to 200 of about 2,682,293 (230)

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

open access: yesBrain Pathology, Volume 36, Issue 6, November 2026.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour   +10 more
wiley   +1 more source

Nature, nurture, and 5‐HT4R: Familial predisposition, not parental bonding, is associated with brain 5‐HT4R in a sex‐specific manner

open access: yesPsychiatry and Clinical Neurosciences, Volume 80, Issue 11, Page 898-904, November 2026.
Background Major depressive disorder (MDD) aggregates in families. The neostriatum, key to reward and attachment circuits, has the highest density of serotonin 4 receptors (5‐HT4R). Striatal 5‐HT4R is low in MDD and linked to familial depression risk. Poor parental bonding increases depression risk, yet whether nature and nurture converge on 5‐HT4R is ...
Randi T. Kjær   +2 more
wiley   +1 more source

Clinical Trajectory of Late‐Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies

open access: yesPsychogeriatrics, Volume 26, Issue 6, November 2026.
ABSTRACT Recent clinical observations indicate that late‐onset psychosis can precede the onset of dementia with Lewy bodies (DLB). However, its longitudinal clinical trajectory remains poorly understood. Delusional disorder (DD) in older adults is relatively uncommon and poor insight frequently leads to refusal of psychiatric care, limiting available ...
Hiroshige Fujishiro   +7 more
wiley   +1 more source

Functional Imaging of Hippocampal Layers Using VASO and BOLD on the Next Generation (NexGen) 7T Scanner

open access: yesHuman Brain Mapping, Volume 47, Issue 15, October 15, 2026.
CBV VASO based fMRI was optimized on NexGen 7T for layer‐specific hippocampal imaging and tested using an autobiographical memory task. Depth dependent activation profiles based on VASO and BOLD images from the same acquisition differed particularly in subiculum, consistent with activation mislocalization in BOLD profiles due to venous bias.
Suvi Häkkinen   +4 more
wiley   +1 more source

NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development. [PDF]

open access: yesNat Neurosci
Sonthalia S   +24 more
europepmc   +1 more source

Seize the Data: A User-Friendly GUI for High-Resolution Analysis of Seizure Dynamics in HD-MEA Recordings. [PDF]

open access: yeseNeuro
Blotter ML   +6 more
europepmc   +1 more source

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