Results 11 to 20 of about 2,682,293 (230)

Neurotransmitters as Modulators of Neural Progenitor Cell Proliferation During Mammalian Neocortex Development

Frontiers in Cell and Developmental Biology, 2020
Neural progenitor cells (NPCs) play a central role during the development and evolution of the mammalian neocortex. Precise temporal and spatial control of NPC proliferation by a concert of cell-intrinsic and cell-extrinsic factors is essential for the ...
Lei Xing, Wieland B. Huttner
doaj   +2 more sources

Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development [PDF]

Nature Communications
Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B.
Lei Xing, Vasiliki Gkini, Anni I. Nieminen, Hui-Chao Zhou, Matilde Aquilino, Ronald Naumann, Katrin Reppe, Kohichi Tanaka, Peter Carmeliet, Oskari Heikinheimo, Svante Pääbo, Wieland B. Huttner, Takashi Namba   +12 more
doaj   +4 more sources

Rethinking Phylogeny and Ontogeny in Hominin Brain Evolution [PDF]

, 2012
Theories of hominin and human cognitive evolution have traditionally focused on the phylogeny of the human brain, and on comparisons of human and primate brains in relation to social or ecological variables.
Coward, Fiona
core   +6 more sources

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures. [PDF]

Adv Sci (Weinh)
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Tóth EZ, Stelcz R, Bod R, Petik Á, Juhász E, Tóth K, Szalai L, Essam N, Somogyi F, Kovács B, Mojtahedzadeh A, Bagó AG, Erőss L, Orbay P, Szabó JP, Fabó D, Hajnal B, Rácz B, Hillier D, Ulbert I, Wittner L.   +20 more
europepmc   +2 more sources

Die Entwicklung des menschlichen Neocortex aus Sicht der Paläogenetik [PDF]

, 2023
Die Vergrößerung des Neocortex während der Evolution des modernen Menschen erfordert eine enorme Teilungsfähigkeit neuronaler Stammund Vorläuferzellen sowie hohe Präzision bei der Verteilung des Erbguts auf die Tochterzellen. Welche Gene dazu beigetragen
Hille-Rehfeld, Annette
core   +1 more source

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

eLife, 2018
The evolutionary increase in size and complexity of the primate neocortex is thought to underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene that, based on its expression pattern in fetal human neocortex and progenitor ...
Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R Long, Milos Kostic, Barbara Langen, Wieland B Huttner   +7 more
doaj   +1 more source

in mice leads to neocortex expansion and increased memory flexibility

, 2021
Neocortex expansion during human evolution provides a basis for our enhanced cognitive abilities. Yet, which genes implicated in neocortex expansion are actually responsible for higher cognitive abilities is unknown.
Pinson, A., Florio, Marta, Prochazka, Jan, Radislav Sedlacek, Wieland B Huttner, Kubik-Zahorodna, Agnieszka, Sedlacek, R., Namba, T., Florio, M., Agnieszka Kubik‐Zahorodna, Anneline Pinson, Sarov, M., Sarov, Mihail, Xing, L., Namba, Takashi, Jan Prochazka, Prochazka, J., Pinson, Anneline, Lei Xing, Sedlacek, Radislav, Huttner, Wieland B, Mihail Sarov, Kubik-Zahorodna, A., Huttner, W., Takashi Namba, Marta Florio, Xing, Lei   +26 more
core   +1 more source

Metabolic Regulation of Neocortical Expansion in Development and Evolution. [PDF]

, 2021
The neocortex, the seat of our higher cognitive abilities, has expanded in size during the evolution of certain mammals such as primates, including humans.
Nardelli, J., Huttner, W., Nardelli, Jeannette, Huttner, Wieland B., Gressens, P., Namba, Takashi, Gressens, Pierre, Namba, T., Jeannette Nardelli, Wieland B. Huttner, Pierre Gressens, Takashi Namba   +11 more
core   +1 more source

Cortical plasticity within and across lifetimes: How can development inform us about phenotypic transformations?

Frontiers in Human Neuroscience, 2013
The neocortex is the part of the mammalian brain that is involved in perception, cognition, and volitional motor control. It is a highly dynamic structure that is dramatically altered within the lifetime of an animal and in different lineages throughout ...
James C Dooley, Leah eKrubitzer, Leah eKrubitzer   +2 more
doaj   +1 more source

Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution

Frontiers in Cell and Developmental Biology, 2022
During development, the decision of stem and progenitor cells to switch from proliferation to differentiation is of critical importance for the overall size of an organ. Too early a switch will deplete the stem/progenitor cell pool, and too late a switch
Samir Vaid, Wieland B. Huttner
doaj   +1 more source