Results 31 to 40 of about 2,682,293 (230)
Evolving Roles of Notch Signaling in Cortical Development
Frontiers in Neuroscience, 2022 Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian +3 more
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Recent advances in understanding neocortical development [version 1; peer review: 2 approved]
F1000Research, 2019 The neocortex is the largest part of the mammalian brain and is the seat of our higher cognitive functions. This outstanding neural structure increased massively in size and complexity during evolution in a process recapitulated today during the ...
Victor Borrell
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Primary Cilia and Centrosomes in Neocortex Development
Frontiers in Neuroscience, 2021 During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the different types of progenitor cells within the germinal zones of the developing neocortex is a ...
Michaela Wilsch-Bräuninger +1 more
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The secondary loss of gyrencephaly as an example of evolutionary phenotypical reversal
Frontiers in Neuroanatomy, 2013 Gyrencephaly (the folding of the surface of the neocortex) is a mammalian-specific trait present in almost all mammalian orders. Despite the widespread appearance of the trait, little is known about the mechanism of its genesis or its adaptive ...
Iva eKelava +2 more
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Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. [PDF]
, 2008 The size and organization of the brain neocortex has dramatically changed during primate evolution. This is probably due to the emergence of novel genes after duplication events, evolutionary changes in gene expression, and/or acceleration in protein ...
Peschanski, Marc +30 more
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Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis
eLife, 2019 While the human brain is clearly large relative to body size, less is known about the timing of brain and brain component expansion within primates and the relative magnitude of volumetric increases.
Ian F Miller +2 more
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Digitized Fossil Brains: Neocorticalization
Biolinguistics, 2012 This report is based on 3D digital scans of endocasts of 110 species of fossil mammals and 35 species of living mammals. It presents direct evidence of the last 60 million years of brain evolution. Endocasts are casts of the cranial cavity.
Harry J. Jerison
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Absence of Tangentially Migrating Glutamatergic Neurons in the Developing Avian Brain
Cell Reports, 2018 Summary: Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and
Fernando García-Moreno +6 more
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Alzheimer’s Disease and Its Possible Evolutionary Origin: Hypothesis
Cells, 2023 The enormous, 2–3-million-year evolutionary expansion of hominin neocortices to the current enormity enabled humans to take over the planet. However, there appears to have been a glitch, and it occurred without a compensatory expansion of the entorhinal ...
James F. Whitfield +2 more
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Neocortex evolution in primates: the 'social brain' is for females
, 2005 According to the social intelligence hypothesis, relative neocortex size should be directly related to the degree of social complexity. This hypothesis has found support in a number of comparative studies of group size. The relationship between neocortex
Lindenfors, Patrik,
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