Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes [PDF]
Frontiers in Immunology, 2021 Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos +6 more
doaj +3 more sources
Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]
Frontiers in ImmunologyThe neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz +6 more
doaj +3 more sources
“Ways in which the neonatal Fc-receptor is involved in autoimmunity” [PDF]
Journal of Translational Autoimmunity, 2021 Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses ...
Juliette Lamamy +5 more
doaj +2 more sources
The neonatal Fc receptor expression during macrophage differentiation is related to autophagy [PDF]
Frontiers in Immunology, 2022 The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy +8 more
doaj +2 more sources
The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]
Nature CommunicationsArteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw +15 more
doaj +2 more sources
The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
doaj +2 more sources
The neonatal Fc receptor in cancer FcRn in cancer [PDF]
Cancer Medicine, 2020 Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda +4 more
doaj +2 more sources
The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]
PLoS PathogensThe neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na +4 more
doaj +2 more sources
Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]
Nature CommunicationsThe blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse +18 more
doaj +2 more sources
Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis [PDF]
Frontiers in Immunology, 2020 Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction.
Karissa L. Gable +2 more
doaj +2 more sources