Results 1 to 10 of about 109,700 (295)

The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +8 more sources

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]

Nature Communications
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey   +15 more
doaj   +6 more sources

The neonatal Fc receptor is a pan-echovirus receptor. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Echoviruses are associated with aseptic meningitis and induce severe and sometimes fatal disease in neonates and young infants. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor.
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB.   +6 more
europepmc   +7 more sources

Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]

Nature Communications
The blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse, Shraddha S. Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J. Meilandt, Monica K. Wetzel-Smith, Hao Cai, Susan R. Crowell, Van Nguyen, Vivian Lee, Ben Chih, Mandy Kwong, Pamela Chan, Sara Santagostino, Donna Lee, Shan Chung, Greg A. Lazar, James A. Ernst, Jasvinder K. Atwal   +18 more
doaj   +5 more sources

Neonatal Fc receptor is a functional receptor for classical human astrovirus. [PDF]

Genes Cells
Human astrovirus (HAstV) is a global cause of gastroenteritis in infants, the elderly, and the immunocompromised. However, the molecular mechanisms that control its susceptibility are not fully understood, as the functional receptor used by the virus has
Haga K, Tokui T, Miyamoto K, Takai-Todaka R, Kudo S, Ishikawa A, Ishiyama R, Kato A, Yokoyama M, Katayama K, Nakanishi A.   +10 more
europepmc   +6 more sources

The therapeutic age of the neonatal Fc receptor. [PDF]

Nat Rev Immunol, 2023
IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Compared with other immunoglobulins, the role of IgGs is distinguished and enhanced by their high circulating levels, long half-life ...
Pyzik M, Kozicky LK, Gandhi AK, Blumberg RS.   +3 more
europepmc   +4 more sources

The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]

PLoS Pathogens
The neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na, Yang Zheng, Jian-Bo Yang, Hao-Lin Bao, Yan-Dong Tang   +4 more
doaj   +3 more sources

Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis [PDF]

Frontiers in Immunology, 2020
Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction.
Karissa L. Gable, Jeffrey T. Guptill, Jeffrey T. Guptill   +2 more
doaj   +3 more sources

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]

Frontiers in Immunology
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen   +6 more
doaj   +4 more sources

Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis [PDF]

Microorganisms, 2021
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian, Chenxi Li, Xi Liu, Xiangchao Jia, Yuncai Xiao, Zili Li   +5 more
doaj   +3 more sources