The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
doaj +3 more sources
The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]
Nature CommunicationsArteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw +15 more
doaj +3 more sources
Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]
Nature CommunicationsThe blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse +18 more
doaj +3 more sources
The neonatal Fc receptor in cancer FcRn in cancer [PDF]
Cancer Medicine, 2020 Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda +4 more
doaj +3 more sources
Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis [PDF]
Frontiers in Immunology, 2020 Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction.
Karissa L. Gable +2 more
doaj +3 more sources
Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis [PDF]
Microorganisms, 2021 The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian +5 more
doaj +3 more sources
The therapeutic age of the neonatal Fc receptor. [PDF]
Nat Rev Immunol, 2023 IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Compared with other immunoglobulins, the role of IgGs is distinguished and enhanced by their high circulating levels, long half-life ...
Pyzik M +3 more
europepmc +2 more sources
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress. [PDF]
BioDrugsAutoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-antigens.
Gjølberg TT +5 more
europepmc +2 more sources
Neonatal Fc Receptor-Targeted Therapies in Neurology. [PDF]
Neurotherapeutics, 2022 Autoantibodies are increasingly recognized for their pathogenic potential in a growing number of neurological diseases. While myasthenia gravis represents the prototypic antibody (Ab)-mediated neurological disease, many more disorders characterized by ...
Nelke C +4 more
europepmc +2 more sources
Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]
Brain Behav ImmunPreclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of ...
Fiore NT +5 more
europepmc +2 more sources