Results 201 to 210 of about 4,213 (269)

Disparities in the utilization of genetic testing for non‐acquired infantile epileptic spasms syndrome in a single healthcare center in North Carolina

open access: yesEpilepsia Open, Volume 10, Issue 2, Page 477-486, April 2025.
Abstract Objective To investigate disparities in the utilization of genetic sequencing among children with Infantile Epileptic Spasms Syndrome (IESS), a severe early‐onset epilepsy where timely diagnosis and treatment are crucial for improving neurodevelopmental outcomes, previous studies have highlighted disparities in the evaluation and management of
Kenza El Marzouki   +10 more
wiley   +1 more source

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

open access: yesExploration, Volume 5, Issue 2, April 2025.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang   +7 more
wiley   +1 more source

Early Development and Co‐Evolution of Microstructural and Functional Brain Connectomes: A Multi‐Modal MRI Study in Preterm and Full‐Term Infants

open access: yesHuman Brain Mapping, Volume 46, Issue 5, 01 April 2025.
Our study reveals a significant relationship between functional connectivity and underlying microstructure during development that decreases with age and varies across connection types. Despite the progressive maturational decoupling of microstructural and functional connectivity, a shared network structure may underlie changes in both properties ...
Andrea Gondová   +3 more
wiley   +1 more source

Immune Checkpoint Molecules: A Review on Pathways and Immunotherapy Implications

open access: yesImmunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
Immune checkpoint molecules are today's leading targets for immunotherapy, especially in the field of cancer. This review summarizes the most important and recent advances in this field and in different types of cancer. ABSTRACT Background Today, treating cancer patients with monoclonal antibodies (mAbs), by targeting immune checkpoints, is one of the ...
Erfan Rezazadeh‐Gavgani   +4 more
wiley   +1 more source

Alloimmune neonatal neutropenia due to an antibody to the neutrophil Fc- gamma receptor III with maternal deficiency of CD16 antigen [PDF]

open access: bronze, 1991
DF Stroncek   +7 more
openalex   +1 more source

Circulating Growth Differentiation Factor 15 (GDF15) in Paediatric Disease: A Systematic Review

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
ABSTRACT Background Growth Differentiation Factor 15 (GDF15), a nonspecific inflammatory marker and member of the TGF‐β superfamily, has a well‐established role in both inflammation and metabolic modulation, but lacks a comprehensive paediatric literature review.
David W. Kronenberger   +3 more
wiley   +1 more source

Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 80, Issue 4, Page 580-597, April 2025.
Abstract Objectives Functional defecation disorders (FDDs) are common among children worldwide. The prevalence of these disorders has not been clearly described in Europe. This study performed a systematic review and meta‐analysis on the prevalence of FDD in European children and assessed geographical, age, and sex distribution and associated factors ...
Michelle N. Bloem   +5 more
wiley   +1 more source

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