Results 21 to 30 of about 4,213 (269)
The therapeutic age of the neonatal Fc receptor
Nature Reviews Immunology, 2023 IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Compared with other immunoglobulins, the role of IgGs is distinguished and enhanced by their high circulating levels, long half-life and ability to transfer from mother to offspring, properties that are conferred by interactions with ...
Michal Pyzik +3 more
openaire +2 more sources
Expression of Neonatal Fc Receptor in the Eye [PDF]
Investigative Opthalmology & Visual Science, 2014 The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the bloodstream. These functions critically depend on the binding of FcRn to the Fc domain of IgG.
Powner, Michael B +4 more
openaire +3 more sources
Neonatal Fc Receptor: From Immunity to Therapeutics [PDF]
Journal of Clinical Immunology, 2010 The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in
Kuo, Timothy Ting-Chang +6 more
openaire +3 more sources
Research progress on neonatal Fc receptor and its application [PDF]
Journal of Zhejiang University (Medical Sciences), 2021 Neonatal Fc receptor (FcRn) is a specific receptor for immunoglobulin G (IgG) and albumin, which binds to them in a pH-dependent manner and prevents them from lysosomal degradation to keep a long plasma half-life. In addition, FcRn plays an important role in transmembrane transport of IgG and albumin and in antigen presentation. In autoimmune diseases,
Pingli Wang +3 more
openaire +3 more sources
Romiplostim use in pregnant women with immune thrombocytopenia
American Journal of Hematology, Volume 98, Issue 1, Page 31-40, January 2023., 2023 Abstract Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before ...
James B. Bussel +7 more
wiley +1 more source
Genetic and phenotypic spectrum in the NONO‐associated syndromic disorder
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 469-478, February 2023., 2023 Abstract The non‐POU domain‐containing octamer‐binding (NONO) protein is involved in multiple steps of gene regulation such as RNA metabolism and DNA repair. Hemizygous pathogenic variants in the NONO gene were confirmed to cause a rare X‐linked syndromic disorder. Through our in‐house diagnostics and subsequent matchmaking, we identified six unrelated
Franziska Roessler +21 more
wiley +1 more source
Neonatal Fc receptor and IgG-based therapeutics [PDF]
mAbs, 2011 The majority of potent new biologics today are IgG-based molecules that have demonstrated tissue-targeting specificity with favorable clinical response. Several factors determine the efficacy of these products, including target specificity, serum half-life and effector functions via complement-dependent cytotoxicity, antibody-dependent cell-mediated ...
Victoria G. Aveson, Timothy T. Kuo
openaire +2 more sources
Morphologies in‐between: The impact of the first steps on the human talus
The Anatomical Record, Volume 306, Issue 1, Page 124-142, January 2023., 2023 Abstract Objective The development of bipedalism is a very complex activity that contributes to shaping the anatomy of the foot. The talus, which starts ossifying in utero, may account for the developing stages from the late gestational phase onwards.
Carla Figus +21 more
wiley +1 more source
Biomedical Chromatography, Volume 37, Issue 1, January 2023., 2023 Abstract Preterm birth and enteral feeding are two main factors leading to necrotizing enterocolitis (NEC). The metabolomics of preterm infants before and after feeding can provide a basis for the prediction of NEC. Using the method of cross‐sectional study, the mode was established with the serum samples of 19 premature infants at birth and after ...
Fusheng Wang +5 more
wiley +1 more source
mAbs, 2020 The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun +3 more
doaj +1 more source