Results 21 to 30 of about 109,700 (295)

The neonatal Fc receptor expression during macrophage differentiation is related to autophagy [PDF]

Frontiers in Immunology, 2022
The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy, Anthony Larue, Julie Mariot, Christine Dhommée, Marie-Véronique Demattei, Yves Delneste, Yves Delneste, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +8 more
doaj   +2 more sources

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) [PDF]

Journal of Biological Chemistry, 2006
We describe here the functional implications of an increase in IgG binding to the neonatal Fc receptor. We have defined in a systematic fashion the relationship between enhanced FcRn binding of a humanized anti-respiratory sincytial virus (RSV ...
William F. Dall’Acqua, Peter A. Kiener, Herren Wu   +2 more
openalex   +2 more sources

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

mAbs, 2019
The neonatal Fc receptor (FcRn) promotes antibody recycling through rescue from normal lysosomal degradation. The binding interaction is pH-dependent with high affinity at low pH, but not under physiological pH conditions.
Brian C. Mackness, Julie A. Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Christine Mauriac, Olivier Pasquier, Thorsten Schmidt, Mostafa Kabiri, Abdullah Kandira, Katarina Radošević, Huawei Qiu   +11 more
doaj   +2 more sources

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody. [PDF]

MAbs
Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as they can ...
Schlein E, Andersson KG, Dallas T, Syvänen S, Sehlin D.   +4 more
europepmc   +2 more sources

Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. [PDF]

Am J Hematol
The neonatal fragment crystallizable (Fc) receptor (FcRn) transports IgG across mucosal surfaces and the placenta and protects IgG from degradation.
Jacobs JW, Booth GS, Raza S, Clark LM, Fasano RM, Gavriilaki E, Abels EA, Binns TC, Duque MA, McQuilten ZK, Mingot-Castellano ME, Savani BN, Sharma D, Tran MH, Tormey CA, Moise KJ, Bloch EM, Adkins BD.   +17 more
europepmc   +2 more sources

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics [PDF]

mAbs, 2017
A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG.
Nicole Piche‐Nicholas, Lindsay B. Avery, Amy King, Mania Kavosi, Mengmeng Wang, Denise M. O’Hara, Lioudmila Tchistiakova, Madan Katragadda   +7 more
openalex   +2 more sources

To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India

Journal of Indian Association of Pediatric Surgeons, 2022
Background: Neonatal sepsis term is an infection of newborns
Sarita Chowdhary, Kanika Sharma, Ashish Ashish, Abhay Kumar Yadav, Pranay Panigrahi, Akas Mishra, Deepak Kumar, Royana Singh   +7 more
doaj   +2 more sources

The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating. [PDF]

J Virol
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release.
Yang K, Dong J, Li J, Zhou R, Jia X, Sun Z, Zhang W, Li Z.   +7 more
europepmc   +2 more sources

Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway. [PDF]

ACS Omega
Ulcerative colitis (UC) is a chronic autoimmune disease (AID) that causes mild to moderate, unpredictable symptoms, including diarrhea and abdominal pain.
Hu H, Lu F, Guan X, Jiang X, Wen C, Wang L.   +5 more
europepmc   +2 more sources

Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy. [PDF]

Eur J Neurol
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease with humoral and cellular autoimmunity causing demyelination of peripheral nerves, commonly treated with intravenous immunoglobulins (IVIg). The neonatal Fc receptor (FcRn),
Fisse AL, Schäfer E, Hieke A, Schröder M, Klimas R, Brünger J, Huckemann S, Grüter T, Sgodzai M, Schneider-Gold C, Gold R, Nguyen HP, Pitarokoili K, Motte J, Arning L.   +14 more
europepmc   +2 more sources