Results 31 to 40 of about 109,700 (295)

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity [PDF]

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +3 more sources

The Neonatal Fc Receptor Is Elevated in Monocyte-Derived Immune Cells in Pancreatic Cancer. [PDF]

Int J Mol Sci, 2022
Thomas J, Torok MA, Agrawal K, Pfau T, Vu TT, Lyberger J, Chang H, Castillo AMM, Chen M, Remaily B, Kim K, Xie Z, Dillhoff ME, Kulp SK, Behbehani GK, Cruz-Monserrate Z, Ganesan LP, Owen DH, Phelps MA, Coss CC, Mace TA.   +20 more
europepmc   +3 more sources

The neonatal Fc receptor in mucosal immune regulation [PDF]

Scandinavian Journal of Immunology, 2020
The neonatal Fc receptor (FcRn) was first recognized for its role in transfer of maternal IgG to the foetus or newborn, providing passive immunity early in life.
K. Aaen, A. Anthi, I. Sandlie, Jeannette Nilsen, S. Mester, J. Andersen   +5 more
semanticscholar   +3 more sources

Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal-fetal immune cytopenias. [PDF]

Transfusion, 2021
Wyckoff SL, Hudson KE.
europepmc   +3 more sources

Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis. [PDF]

MAbs, 2019
The maintenance of the homeostasis of immunoglobulin G (IgG) represents a fundamental aspect of humoral immunity that has direct relevance to the successful delivery of antibody-based therapeutics.
Challa DK, Wang X, Montoyo HP, Velmurugan R, Ober RJ, Ward ES.   +5 more
europepmc   +2 more sources

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. [PDF]

Br J Pharmacol, 2020
Pemphigus and pemphigoid diseases are characterized and caused predominantly by IgG autoantibodies targeting structural proteins of the skin. Their current treatment relies on general and prolonged immunosuppression that causes severe adverse events ...
Kasprick A, Hofrichter M, Smith B, Ward P, Bieber K, Shock A, Ludwig RJ, Schmidt E.   +7 more
europepmc   +2 more sources

Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications [PDF]

Frontiers in Immunology, 2015
As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation.
Timo eRath, Timo eRath, Kristi eBaker, Michal ePyzik, Richard S. Blumberg   +4 more
doaj   +5 more sources

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]

Brain Behav Immun
Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.   +5 more
europepmc   +2 more sources

The neonatal Fc receptor: Key to homeostasic control of IgG and IgG-related biopharmaceuticals. [PDF]

Am J Transplant, 2019
IgG and albumin are the most abundant proteins in the circulation and have the longest half‐lives. These properties are due to a unique receptor, the neonatal Fc receptor (FcRn).
Baldwin WM, Valujskikh A, Fairchild RL.
europepmc   +2 more sources

Lack of neonatal Fc receptor does not diminish the efficacy of the HSV-1 0ΔNLS vaccine against ocular HSV-1 challenge. [PDF]

Vaccine, 2021
Carr DJJ, Berube AN, Filiberti A, Gmyrek GB.   +3 more
europepmc   +3 more sources