Frontiers in Immunology, 2015 The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism.
Kine Marita Knudsen Sand +10 more
doaj +1 more source
Journal of Biological EngineeringBackground Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient ...
Sanghwan Ko +8 more
doaj +1 more source
Low immunogenicity of insulin efsitora alfa in participants with type 1 and type 2 diabetes mellitus
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1350-1358, February 2026.Abstract Aims To evaluate treatment‐emergent antidrug antibodies (TE ADA) in once‐weekly basal insulin efsitora‐treated participants with type 1 and type 2 diabetes mellitus (T1DM and T2DM) from 5 phase 3 clinical trials and their potential impact on pharmacokinetics, efficacy and safety.
Yun Wang +8 more
wiley +1 more source
Analysis of a compartmental model of endogenous immunoglobulin G metabolism with application to multiple myeloma [PDF]
, 2017 Immunoglobulin G (IgG) metabolism has received much attention in the literature for two reasons: (i) IgG homeostasis is regulated by the neonatal Fc receptor (FcRn), by a pH-dependent and saturable recycling process, which presents an interesting ...
Arnulf, Bertrand +17 more
core +2 more sources
A szarvasmarha neonatalis Fc receptor (bFcRn) által mediált IgG katabolizmus és epithelialis transzport molekuláris szintű elemzése = Studies on the bovine FcRn mediated IgG catabolism and epithelial transport at molecular level [PDF]
, 2009 A pályázat révén jelentősen bővítettük a szarvasmarha FcRn (bFcRn) szerepéről alkotott ismereteinket arról hogyan szabályozza ez a receptor az IgG homeosztázisát.
Doleschall, Márton +5 more
core
Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca [PDF]
, 2015 Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection.
Burchmore, Richard J. S. +9 more
core +1 more source
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]
, 2019 Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J. +10 more
core +2 more sources
Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]
, 2019 Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl +6 more
core +1 more source
Neonatal immune tolerance induction to allow long-term studies with an immunogenic therapeutic monoclonal antibody in mice [PDF]
, 2015 The purpose of this study is to test the feasibility of neonatal immune tolerance induction in mice to enable long-term pharmacokinetic studies with immunogenic therapeutic monoclonal antibodies (mAb). Neonatal immune tolerance was induced by transfer
Bessa, Juliana +5 more
core +1 more source
Immunogenicity of long-lasting recombinant factor VIII products [PDF]
, 2016 International audienceReplacement therapy for patients with hemophilia A using plasma-derived or recombinant factor VIII (FVIII) is complicated by the short half-life of the FVIII products and by the occurrence of neutralizing antibodies in a substantial
Delignat, Sandrine +6 more
core +4 more sources