Serum albumin and its interaction with the neonatal Fc receptor (FcRn) : characterization of the albumin/FcRn-binding mechanism [PDF]
, 2013 In the past a lot of different biomolecular therapeutics were developed. A common problem using small molecules in therapy is their reduced serum concentration after short time period. The human body clears therapeutic molecules which have a size beneath the kidney clearance threshold in minutes to hours.
openaire +2 more sources
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life
iScience, 2022 Summary: Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants of ...
Algirdas Grevys +12 more
doaj
Cause-of-death estimates for the early and late neonatal periods for 194 countries from 2000-2013 [PDF]
arXiv, 2014 Objective: Cause-of-death distributions are important for prioritising interventions. We estimated proportions, risks, and numbers of deaths (with uncertainty) for programme-relevant causes of neonatal death for 194 countries for 2000-2013, differentiating between the early (days 0-6) and late (days 7-27) neonatal periods.
arxiv
Automatic Coding for Neonatal Jaundice From Free Text Data Using Ensemble Methods [PDF]
arXiv, 2018 This study explores the creation of a machine learning model to automatically identify whether a Neonatal Intensive Care Unit (NICU) patient was diagnosed with neonatal jaundice during a particular hospitalization based on their associated clinical notes.
arxiv
A Single Channel-Based Neonatal Sleep-Wake Classification using Hjorth Parameters and Improved Gradient Boosting [PDF]
arXivSleep plays a crucial role in neonatal development. Monitoring the sleep patterns in neonates in a Neonatal Intensive Care Unit (NICU) is imperative for understanding the maturation process. While polysomnography (PSG) is considered the best practice for sleep classification, its expense and reliance on human annotation pose challenges.
arxiv
Correction for Wani et al., Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant β 2 -microglobulin gene [PDF]
, 2006 openalex +1 more source
Accelerated, Robust Lower-Field Neonatal MRI with Generative Models [PDF]
arXivNeonatal Magnetic Resonance Imaging (MRI) enables non-invasive assessment of potential brain abnormalities during the critical phase of early life development. Recently, interest has developed in lower field (i.e., below 1.5 Tesla) MRI systems that trade-off magnetic field strength for portability and access in the neonatal intensive care unit (NICU ...
arxiv