Results 21 to 30 of about 7,511 (210)

Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn

PLoS ONE, 2012
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation. We have previously shown that overexpression of FcRn in transgenic mice significantly improves the humoral immune response.
Ana Paula Catunda Lemos, Judit Cervenak, Balázs Bender, Orsolya Ivett Hoffmann, Mária Baranyi, Andrea Kerekes, Anita Farkas, Zsuzsanna Bösze, László Hiripi, Imre Kacskovıcs   +9 more
openalex   +8 more sources

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn [PDF]

Proceedings of the National Academy of Sciences, 2008
The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-livesin vivoby protecting them from intracellular catabolism and then returning them to the extracellular space. Other investigators have demonstrated that mice lacking FcRn are protected from induction of various autoimmune diseases, presumably because of the ...
Adam R. Mezo, Kevin McDonnell, Cristina A. Tan Hehir, Susan C. Low, Vito J. Palombella, James M. Stattel, George D. Kamphaus, Cara Fraley, Yixia Zhang, Jennifer Dumont, Alan J. Bitonti   +10 more
openalex   +6 more sources

Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells [PDF]

Immunology, 1997
Maternal IgG is transferred to the suckling mouse and rat through a major histocompatibility complex (MHC) class I‐related Fc receptor (FcRn) on the brush border of the proximal small intestine. We have previously described a site on the epithelial surface of the human fetal intestine with IgG binding characteristics similar to FcRn. We report here the
Esther J. Israel, Shirley M. Taylor, Zhenping Wu, Emiko Mizoguchi, Richard S. Blumberg, Atul K. Bhan, Neil E. Simister   +6 more
openalex   +4 more sources

FcRn-guided antigen trafficking enhances cancer vaccine efficacy [PDF]

Cancer Immunology, Immunotherapy
The development of tumor vaccines represents a significant focus within cancer therapeutics research. Nonetheless, the efficiency of antigen presentation in tumor vaccine remains suboptimal.
Mengyu Hong, Muziying Liu, Fang Zhu, Dan Zhao, Guilai Liu, Tiyun Han, Caiyi Fei, Weihong Zeng, Shi Chen, Qiqin Wu, Bofeng Li, Songquan Wu, Yuhua Shang, Huan Ma, Shoubing Zhou, Shi Xu, Tengchuan Jin   +16 more
doaj   +2 more sources

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) [PDF]

Journal of Biological Chemistry, 2006
We describe here the functional implications of an increase in IgG binding to the neonatal Fc receptor. We have defined in a systematic fashion the relationship between enhanced FcRn binding of a humanized anti-respiratory syncytial virus (RSV) monoclonal antibody (MEDI-524) and the corresponding biological consequences in cynomolgus monkeys.
William F. Dall’Acqua, Peter A. Kiener, Herren Wu   +2 more
openalex   +5 more sources

Neonatal Fc receptor (FcRn) – not only transporter of maternal IgG

Postępy Higieny i Medycyny Doświadczalnej, 2018
The neonatal Fc receptor, (FcRn) is a transmembrane, heterodimeric glycoprotein with a structure similar to MHC class I molecules. In contrast to MHC class I antigens, FcRn does not bind to peptides (antigens) but interacts with the Fc fragment of IgG and albumin.
J Mikulska
openalex   +2 more sources

Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice [PDF]

Mucosal Immunology, 2011
Neonatal Fc receptors for immunoglobulin (Ig)G (FcRn) assume a central role in regulating host IgG levels and IgG transport across polarized epithelial barriers. We have attempted to elucidate the contribution of FcRn in controlling Helicobacter infection in the stomach.
Yahaya Ben Suleiman, Masaru Yoshida, Shin Nishiumi, Hiroshi Tanaka, Takuya Mimura, Kentaro Nobutani, Koji Yamamoto, Mamoru Takenaka, A Aoganghua, Ikuya Miki, Hiroyoshi Ota, Shinʼichi Takahashi, Hidenori Matsui, Masahiko Nakamura, Richard S. Blumberg, Takeshi Azuma   +15 more
openalex   +4 more sources

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes

Frontiers in Immunology, 2021
Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos, Slobodan Culina, Claire Deligne, Cassandra Lavaud, Sylvaine You, Roberto Mallone, Roberto Mallone   +6 more
doaj   +1 more source

Neonatal Fc Receptor (FcRn) Enhances Tissue Distribution and Prevents Excretion of nab-Paclitaxel. [PDF]

Mol Pharm, 2019
nab-Paclitaxel ( nab-P), an albumin-bound formulation of paclitaxel, was developed to improve the tolerability and antitumor activity of taxanes. The neonatal Fc receptor (FcRn) is a transport protein that can bind to albumin and regulate the homeostasis of circulating albumin.
Li F, Yuan H, Zhang H, He M, Liao J, Chen N, Li Y, Zhou S, Palmisano M, Yu A, Pai M, Sun D.   +11 more
europepmc   +5 more sources

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source