Results 21 to 30 of about 8,086 (233)

Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. [PDF]

Am J Hematol
AbstractThe neonatal fragment crystallizable (Fc) receptor (FcRn) transports IgG across mucosal surfaces and the placenta and protects IgG from degradation. Numerous clinical trials are investigating therapeutic FcRn inhibition for various immune‐mediated neuromuscular and rheumatologic conditions; however, FcRn inhibition also represents a potential ...
Jacobs JW, Booth GS, Raza S, Clark LM, Fasano RM, Gavriilaki E, Abels EA, Binns TC, Duque MA, McQuilten ZK, Mingot-Castellano ME, Savani BN, Sharma D, Tran MH, Tormey CA, Moise KJ, Bloch EM, Adkins BD.   +17 more
europepmc   +6 more sources

Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis. [PDF]

Immunol Res
AbstractThe inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to reduce the amount of circulating pathogenic IgG autoantibodies by interfering with their recycling system. FcRn antibodies are currently being tested in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Mausberg AK, Szepanowski F, Eggert B, Liebig KC, Kleinschnitz C, Kieseier BC, Stettner M.   +6 more
europepmc   +6 more sources

Neonatal Fc Receptor (FcRn) Enhances Tissue Distribution and Prevents Excretion of nab-Paclitaxel. [PDF]

Mol Pharm, 2019
nab-Paclitaxel ( nab-P), an albumin-bound formulation of paclitaxel, was developed to improve the tolerability and antitumor activity of taxanes. The neonatal Fc receptor (FcRn) is a transport protein that can bind to albumin and regulate the homeostasis of circulating albumin.
Li F, Yuan H, Zhang H, He M, Liao J, Chen N, Li Y, Zhou S, Palmisano M, Yu A, Pai M, Sun D.   +11 more
europepmc   +6 more sources

Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal-fetal immune cytopenias. [PDF]

Transfusion, 2021
Wyckoff SL, Hudson KE.
europepmc   +3 more sources

Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]

Nature Communications
Human astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz, Sarah Lanning, Khurshid R. Iranpur, Lena Ricemeyer, Carlos F. Arias, Rebecca M. DuBois   +5 more
doaj   +2 more sources

Interactions of IgG1 CH2 and CH3 domains with FcRn [PDF]

Frontiers in Immunology, 2014
Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, when compared to full-size antibodies, most of the current antibody fragments of VH or VL display greatly reduced
Tianlei eYing, Tina W Ju, Yanping eWang, Ponraj ePrabakaran, Dimiter S Dimitrov   +4 more
doaj   +3 more sources

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis. [PDF]

PLoS One, 2020
Dylewski JF, Tonsawan P, Garcia G, Lewis L, Blaine J.   +4 more
europepmc   +2 more sources

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics. [PDF]

MAbs, 2018
Piche-Nicholas NM, Avery LB, King AC, Kavosi M, Wang M, O'Hara DM, Tchistiakova L, Katragadda M.   +7 more
europepmc   +3 more sources

Albumin Levels Are Predictive of Cachexia-Induced Time-Dependent Clearance of Therapeutic Antibodies: A Physiologically Based Pharmacokinetic Model of Durvalumab. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Cachexia is a metabolic condition that accelerates the clearance of monoclonal antibodies in cancer patients and is a known mechanism causing time‐dependent clearance. Successful anticancer treatment often ameliorates symptoms of cachexia, reducing the drug clearance over time especially in patients who respond. Serum albumin level is a common
Proctor JR, Wong H.
europepmc   +2 more sources

PSIII-7 Evaluation of Maternal Selenium Supplementation and Plane of Nutrition During Gestation on the Neonatal Fc Receptor (Fcrn) in Lamb Intestinal Tissue [PDF]

J Anim Sci, 2022
Maverick C Guenther, C.J. Hammer, Rachel A Voigt, Pawel P. Borowicz, Tammi L Neville, K. A. Vonnahme, Dale A. Redmer, Lawrence P. Reynolds, Joel S Caton   +8 more
europepmc   +3 more sources