Results 31 to 40 of about 8,086 (233)

Single‐cell atlas reveals heterogeneous response to FcRn blockade in anti‐AChR antibody‐positive generalised myasthenia gravis [PDF]

Clinical and Translational Medicine
Background Myasthenia gravis (MG) is an autoimmune disease predominantly driven by autoantibodies targeting acetylcholine receptor (AChR), resulting in muscle weakness.
Hui‐Ning Li, Jingjing Liu, Xiao‐Yu Huang, Lijie Zhu, Zhirui Liu, Chun‐Sheng Yang, Bo Zhang, Shixiong Huang, Fu‐Dong Shi, Zhigang Cai, Chao Zhang   +10 more
doaj   +2 more sources

Neonatal Fc receptor (FcRn) – not only transporter of maternal IgG

Postępy Higieny i Medycyny Doświadczalnej, 2018
The neonatal Fc receptor, (FcRn) is a transmembrane, heterodimeric glycoprotein with a structure similar to MHC class I molecules. In contrast to MHC class I antigens, FcRn does not bind to peptides (antigens) but interacts with the Fc fragment of IgG and albumin.
J Mikulska
openalex   +2 more sources

The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells [PDF]

, 2020
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody.
Sandeep Kumar Gupta, Johannes S. Gach, Juan Carlos Aldave Becerra, Tran B. Phan, Jeffrey Pudney, Zina Moldoveanu, Sarah Joseph, Gary Landucci, Medalyn Supnet, Li‐Hua Ping, Davide Corti, Brian Moldt, Zdeněk Hel, Antonio Lanzavecchia, Ruth M. Ruprecht, Dennis R. Burton, Jiří Městecký, Deborah J. Anderson, Donald N. Forthal   +18 more
openalex   +7 more sources

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn [PDF]

Seminars in Immunopathology, 2009
Careful regulation of the body's immunoglobulin-G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn) which, as a single receptor, is capable of regulating both of these molecules, has become an important focus of investigation.
Kristi Baker, Shuo‐Wang Qiao, Timothy Kuo, Kanna Kobayashi, Masaru Yoshida, Wayne I. Lencer, Richard S. Blumberg   +6 more
openalex   +4 more sources

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]

Brain Behav Immun
Preclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of pronociceptive IgG, which accumulates around the lumbar region, including within the dorsal root ganglia
Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.   +5 more
europepmc   +3 more sources

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. [PDF]

Br J Pharmacol, 2020
Background and PurposePemphigus and pemphigoid diseases are characterized and caused predominantly by IgG autoantibodies targeting structural proteins of the skin. Their current treatment relies on general and prolonged immunosuppression that causes severe adverse events, including death.
Kasprick A, Hofrichter M, Smith B, Ward P, Bieber K, Shock A, Ludwig RJ, Schmidt E.   +7 more
europepmc   +4 more sources

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes

Frontiers in Immunology, 2021
Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos, Slobodan Culina, Claire Deligne, Cassandra Lavaud, Sylvaine You, Roberto Mallone, Roberto Mallone   +6 more
doaj   +1 more source

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon   +25 more
doaj   +1 more source