Results 71 to 80 of about 7,511 (210)

“Ways in which the neonatal Fc-receptor is involved in autoimmunity”

Journal of Translational Autoimmunity, 2021
Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses ...
Juliette Lamamy, Pierre Boulard, Guillaume Brachet, Sébastien Tourlet, Valérie Gouilleux-Gruart, Yanis Ramdani   +5 more
doaj  

NeoRS: a neonatal resting state fMRI data preprocessing pipeline [PDF]

arXiv, 2022
Resting state fMRI (rsfMRI) has been shown to be a promising tool to study intrinsic functional connectivity and assess its integrity in cerebral development. In neonates, where fMRI is limited to few paradigms, rsfMRI was shown to be a relevant tool to explore regional interactions of brain networks.
arxiv  

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Frontiers in Immunology, 2018
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth.
Diana Cadena Castaneda, Diana Cadena Castaneda, Christine Dhommée, Christine Dhommée, Thomas Baranek, Thomas Baranek, Emilie Dalloneau, Emilie Dalloneau, Laurie Lajoie, Laurie Lajoie, Alexandre Valayer, Alexandre Valayer, Christophe Arnoult, Christophe Arnoult, Marie-Véronique Demattéi, Marie-Véronique Demattéi, Delphine Fouquenet, Delphine Fouquenet, Christelle Parent, Christelle Parent, Nathalie Heuzé-Vourc'h, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +23 more
doaj   +1 more source

AEC in a NetShell: On Target and Topology Choices for FCRN Acoustic Echo Cancellation [PDF]

arXiv, 2021
Acoustic echo cancellation (AEC) algorithms have a long-term steady role in signal processing, with approaches improving the performance of applications such as automotive hands-free systems, smart home and loudspeaker devices, or web conference systems.
arxiv  

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

iMeta, EarlyView.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng   +17 more
wiley   +1 more source

Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

mAbs, 2023
A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding ...
Thomas Müller, Carolin Tasser, Michael Tesar, Ivica Fucek, Ute Schniegler-Mattox, Joachim Koch, Kristina Ellwanger   +6 more
doaj   +1 more source

Deep Residual Echo Suppression and Noise Reduction: A Multi-Input FCRN Approach in a Hybrid Speech Enhancement System [PDF]

arXiv, 2021
Deep neural network (DNN)-based approaches to acoustic echo cancellation (AEC) and hybrid speech enhancement systems have gained increasing attention recently, introducing significant performance improvements to this research field. Using the fully convolutional recurrent network (FCRN) architecture that is among state of the art topologies for noise ...
arxiv  

Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In 2017, the free and open‐source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into a diverse network of stakeholders committed to advancing open‐source solutions for model‐informed drug development (MIDD). In this context, the first OSP Community Conference was hosted by Novartis in
André Dallmann, Denise Feick, Pavel Balazki, Salih Benamara, Rolf Burghaus, Marylore Chenel, Siak‐Leng Choi, Henrik Cordes, Mariana Guimarães, Abdullah Hamadeh, Ibrahim Ince, Kathleen M. Job, Tobias Kanacher, Andreas Kovar, Lars Kuepfer, Jörg Lippert, Julia Macente, Nina Nauwelaerts, Christoph Niederalt, Sheila Peters, Susana Proença, Masanobu Sato, Stephan Schaller, Jan Frederik Schlender, Annika Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Thomas Wendl, Wilhelmus E. A. de Witte, Donato Teutonico   +31 more
wiley   +1 more source

BioMETA: A multiple specification parameter estimation system for stochastic biochemical models [PDF]

arXiv, 2020
The inherent behavioral variability exhibited by stochastic biochemical systems makes it a challenging task for human experts to manually analyze them. Computational modeling of such systems helps in investigating and predicting the behaviors of the underlying biochemical processes but at the same time introduces the presence of several unknown ...
arxiv