The potential role of neopterin in Covid-19: a new perspective [PDF]
Molecular and Cellular Biochemistry, 2021 Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-γ). NPT is regarded as a macrophage stimulation indicator, marker of cellular immune activation and T helper 1 (Th1) type 1 immune ...
Hayder M. Al‐kuraishy +4 more
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PLoS ONE, 2021 Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker +6 more
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The Effects of Neopterin on the Viability and Motility of Different HCC Cell Lines [PDF]
Proceedings, 2018 Increased neopterin levels reflect the activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases such as cancer.
Imge Kunter +4 more
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Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?
Antioxidants, 2018 Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P. Gieseg +2 more
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Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes. [PDF]
PLoS ONE, 2013 ObjectiveA high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those
Marta Molero-Luis +7 more
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Clinical significance of increased serum neopterin in chronic kidney failure as a biomarker of cell-mediated immunity [PDF]
Journal of Medical Biochemistry, 2019 Background: Neopterin is a pyrazino-pyrimidine compound which is used as a marker of cell-mediated immunity in a variety of diseases. It is known that neopterin levels increase in diseases where interferon-gamma (IFN-g) stimulation is present, and also ...
Ünüvar Songül, Aslanhan Hamza
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Neopterin Counters Vascular Inflammation and Atherosclerosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundNeopterin, a metabolite of GTP, is produced by activated macrophages and is abundantly expressed within atherosclerotic lesions in human aorta and carotid and coronary arteries.
Remina Shirai +12 more
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Pteridines, 1989 Summary A brief review is given on the value of neopterin determination as a biochemical marker for the in vivo activation state of cell-mediated immunity. In a broad spectrum of diseases which are recognized or supposed to involve activation of monocytes/macrophages by interferon gamma derived from activated T lymphocytes, the applicability and ...
Hausen Arno +4 more
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Validation of a Method for the Assessment of Urinary Neopterin Levels to Monitor Health Status in Non-human-primate Species [PDF]
Frontiers in Physiology, 2017 Determining individual health status is of great importance for a better understanding of life history trade-offs between growth, reproduction, and maintenance.
Verena Behringer +4 more
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Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild. [PDF]
Am J PrimatolNeopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Behringer V, Deimel C.
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