Results 91 to 100 of about 182,326 (341)

LncRNAs in ocular neovascularizations

International Journal of Ophthalmology, 2019
The prevalence of eye diseases worldwide is dramatically increasing and represents a major concern in underdeveloped and developed regions. Ocular diseases, previously associated with a higher depression risk, also impose a substantial economic burden on affected families, thus early detection and/or accurate treatment in order to avoid and prevent ...
Min-Ting Chen, Yacouba Cissé, Lang Bai
openaire   +4 more sources

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Peptide Lv and Angiogenesis: A Newly Discovered Angiogenic Peptide

Biomedicines
Peptide Lv is a small endogenous secretory peptide with ~40 amino acids and is highly conserved among certain several species. While it was first discovered that it augments L-type voltage-gated calcium channels (LTCCs) in neurons, thus it was named ...
Dylan L. Pham, Kelsey Cox, Michael L. Ko, Gladys Y.-P. Ko   +3 more
doaj   +1 more source

Microscopically Adaptable Bioink Guide Cell Compartmentalization toward Morphogenesis of a Functional Vasculature‐Like System

Advanced Healthcare Materials, EarlyView.
Contractile vasculatures are fabricated through a one‐step bioprinting strategy. The adaptable microenvironment provided by ECM‐mimicking bioink triggers cell sorting and compartmentalization of endothelial cells and vascular smooth muscle cells toward a histological configuration by focal adhesion kinase‐mediated upregulation of cell adhesion and ...
Jun Chen, Yuqiong Wu, Jiarong Huang, Junjin Jie, Chan Huang, Di Zhang, Yuxin Huang, Rui Mao, Ming Zhao, Lin‐Ping Wu   +9 more
wiley   +1 more source

Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo

Frontiers in Cell and Developmental Biology
IntroductionVascular endothelial growth factor (VEGF) inhibition is currently the first-line therapy for various retinal vascular disorders, however there is a strong need to develop novel therapies to target other molecules involved in the angiogenic ...
María Lina Formica, María Constanza Paz, María Constanza Paz, María Victoria Vaglienti, María Victoria Vaglienti, Paula Virginia Subirada, Paula Virginia Subirada, Yamila Fernández, Yamila Fernández, Mariana Belén Joray, José Domingo Luna, Pablo Federico Barcelona, Pablo Federico Barcelona, Santiago Daniel Palma, María Cecilia Sánchez, María Cecilia Sánchez   +15 more
doaj   +1 more source

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates

Frontiers in Endocrinology, 2019
Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and ...
Hannah R. Bender, Genevieve E. Campbell, Priyanka Aytoda, Allison H. Mathiesen, Diane M. Duffy   +4 more
doaj   +1 more source

Therapeutic vascularization in regenerative medicine

Stem Cells Translational Medicine, 2020
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue‐engineered constructs and to treat ischemic conditions.
Roberto Gianni‐Barrera, Nunzia Di Maggio, Ludovic Melly, Maximilian G. Burger, Edin Mujagic, Lorenz Gürke, Dirk J. Schaefer, Andrea Banfi   +7 more
doaj   +1 more source

Poly(hydroxy‐oxazolidone) Thermoplastic Elastomers for Safer, Greener and Customizable Blood‐Contacting Medical Devices

Advanced Healthcare Materials, EarlyView.
A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo, Anna Pierrard, Fréderic Lifrange, Marco Caliari, Céline D'Emal, Margaux Debuisson, Haritz Sardon, Philippe Delvenne, Patrizio Lancellotti, Christophe Detrembleur, Christine Jérôme, Cécile Oury   +11 more
wiley   +1 more source

Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

eLife, 2019
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation.
Wenxin Ma, Sean M Silverman, Lian Zhao, Rafael Villasmil, Maria M Campos, Juan Amaral, Wai T Wong   +6 more
doaj   +1 more source

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction - (TOPCARE-AMI) [PDF]

, 2002
Background - Experimental studies suggest that transplantation of blood-derived or bone marrow–derived progenitor cells beneficially affects postinfarction remodeling.
Aicher, A, Assmus, B, Britten, M, Dimmeler, S, Döbert, N, Grünwald, F, Hoelzer, D, Lehmann, R, Martin, H, Schächinger, V, Teupe, C, Urbich, C, Zeiher, AM   +12 more
core   +1 more source