Results 121 to 130 of about 8,883 (209)

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor

, 2016
Nephrin belongs to a family of highly conserved proteins with a well characterized function as modulators of cell adhesion and guidance, and nephrin may have a role in metabolic pathways linked to podocyte and pancreatic β-cell survival.
Maiguel, Dony, Jeon, Jongmin, Grahammer, Florian, Yoo, Tae H., Leibiger, Ingo B., Fachado, Alberto, Busher Katin, Anja, Berggren, Per-Olof, Oh, Jun, Villarreal, Rodrigo, Yoo, Tae H, Burke, George W., Mitrofanova, Alla, Burke, George W, Huber, Tobias B., Merscher, Sandra, Huber, Tobias B, Morales, Ximena, Leibiger, Ingo B, Gellermann, Jutta, Guzman, Johanna, Fornoni, Alessia   +21 more
core   +1 more source

Nephrin deficiency activates NF-κB and promotes glomerular injury

, 2009
Increasing evidence implicates activation of NF-κB in a variety of glomerular diseases, but the mechanisms involved are unknown. Here, upregulation of NF-κB in the podocytes of transgenic mice resulted in glomerulosclerosis and proteinuria.
Serrano, Manuel, Hussain, S, Diaz-Meco, M, Scambler, P, Scambler, Peter, Diaz-Meco, Maria, Mathieson, P, Mathieson, Peter, Serrano, M, Romio, Leile, Romio, L, Moscat, Jorge, Koziell, A, Moscat, J, Hussain, Sagair, Koziell, Ania, Saleem, M, Saleem, MA, Mathieson, PW, Saleem, Moin   +19 more
core   +1 more source

Autophagy in patients with lupus nephritis and its effect on podocyte related protein expression

Linchuang shenzangbing zazhi, 2020
Objective To investigate the autophagy in patients with lupus nephritis(LN)and its effect on podocyte related protein expression.Methods A total of 69 LN patients(LN group),including 50 cases of systemic lupus erythematosus(SLE group)and 50 patients with
LI Zhang-hong, ZHANG Rui-rui, LUO Qiu-ju
doaj  

Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases11See Editorial by Mathieson, p. 756.

, 2003
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases.BackgroundNephrin is a recently discovered protein of the immunoglobulin (Ig) superfamily.
Xiao Li Liu, Vesa Ruotsalainen, Liu, Xiao Li, Tryggvason, Karl, Reponen, Paula, Juhani Lahdenperä, Pekka Kilpeläinen, Paula Reponen, Pikkarainen, Timo, Timo Pikkarainen, Karl Tryggvason, Lahdenperä, Juhani, Kilpeläinen, Pekka, Ruotsalainen, Vesa   +13 more
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厄贝沙坦对早期糖尿病肾脏疾病大鼠足细胞nephrin和podocin表达的影响

Linchuang shenzangbing zazhi, 2014
目的 观察厄贝沙坦（irbesartan）对糖尿病肾脏疾病（diabetic kidney disease,DKD）大鼠足细胞裂孔隔膜蛋白分子（nephrin和podocin）表达的影响,探讨厄贝沙坦对DKD的防治作用。方法 以高脂高糖喂养8周联合小剂量链脲佐菌素（30 rmg/kg）建立DKD大鼠模型,将DKD大鼠模型随机分为2组:厄贝沙坦组及模型对照组;另设正常对照组。厄贝沙坦组给予厄旦沙坦(50 mg·kg-1·d-1),另外2组每日给予等量0.9%生理盐水灌胃。各组于治疗前及药物干预后第4、8 ...
岳少姮
doaj  

Nephrotic syndrome caused by recurrent podocytopathy after living donor renal transplantation with elevated anti-nephrin antibody levels: a case report and a review

Renal Replacement Therapy
Background Approximately 95% of patients with idiopathic nephrotic syndrome (INS) have a favorable prognosis, though 4–5% progress to end-stage renal disease. The recurrence rate of INS following kidney transplantation is approximately 30%.
Ryoichi Miyazaki, Kyoko Miyagi, Tatsuhito Miyanaga, Yoko Shirai, Kenichiro Miura, Motoshi Hattori, Satoshi Hara, Kiyoaki Ito, Ichiro Mizushima, Yasunori Iwata   +9 more
doaj   +1 more source

骨形态发生蛋白-7通过TGFβ/smad信号通路抑制高糖诱导下足细胞的转分化

Zhongguo shiyan zhenduanxue, 2014
目的通过观察骨形态发生蛋白-7（BMP-7）对高糖环境培养下足细胞p-smad2/3、nephrin、desmin表达的影响探讨BMP-7抑制足细胞转分化机制。方法以体外培养的小鼠永生化足细胞为研究对象,将其分为以下4组:正常糖组（NG组,含D-葡萄糖5.5mmol/L）、高糖刺激组（HG组,含D-葡萄糖30mmol/L）、高糖+BMP-7干预组（BMP-7组,含D-葡萄糖30mmol/L+400ng/ml rhBMP-7）、甘露醇对照组（MN组,含D-葡萄糖5.5mmol/L+甘露醇24.5mmol ...
徐建伟, 刘丽秋, 赵小丽
doaj  

Nephrine [PDF]

, 2019
openaire   +1 more source

Nephrin : intracellular trafficking and podocyte maturation [Elektronisk resurs]

, 2007
Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal recessive disorder caused by mutations in the NPHS1 gene and, consequently, in its product nephrin, a 180 kDa transmembrane protein belonging to the immunoglobulin superfamily of ...
Cotta, Doné S,
core  

A causal link or coincidence? Anti-nephrin antibody-positive minimal change disease coexisting with neuroblastoma in a child. [PDF]

BMC Nephrol
Li H, Zhao S, Che R.
europepmc   +1 more source