Results 101 to 110 of about 8,883 (209)

A pilot study on genetic variation in purine-rich elements in the nephrin gene promoter in type 2 diabetic patients

Biological Research, 2007
Diabetic nephropathy (DN) is one of the major complications of type 2 diabetes and is associated with coronary disease. Nephrin, a protein mainly expressed in glomeruli, is decreased in DN and other kidney diseases.
RODRIGO GONZÁLEZ, ARES TIRADO, MONSERRAT BALANDA, MIRIAM ALVO, INÉS BARQUÍN, PILAR DURRUTY, SERGIO LOBOS, DANIELA SEELENFREUND   +7 more
doaj  

Proteinuria in Primary and Secondary Renal Diseases [PDF]

Journal of Clinical and Diagnostic Research, 2012
Proteinuria is a strong indicator of kidney disease. Various pathological conditions such as diabetes mellitus, cardiovascular disease and hypertension have been shown to provoke secondary kidney problems and significant proteinuria.
Anuradha B. Patil, C.V. B. Prasad, Shivaprasad S.   +2 more
doaj  

SAT-439 PODOCIN REGULATES THE NEPHRIN-NEPHRIN DISTANCE IN THE GLOMERULAR PORE [PDF]

Kidney International Reports, 2020
M. KÉTSZERI, V. Antal, G. Schay, A. Ungvári-Veres, K. Csókay, M. Kellermayer, D. Karancsiné Menyhárd, K. Tory   +7 more
openaire   +1 more source

Molecular basis of the functional podocin-nephrin complex:mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

, 2003
Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy proteinuria and renal failure. Mutations of NPHS1 or NPHS2, the genes encoding for nephrin and podocin, lead to early onset of heavy proteinuria, and rapid progression to ...
Simons, Matias, Benzing, Thomas, Huber, Tobias B, Hartleben, Björn, Walz, Gerd, Sernetz, Leonie, Schmidts, Miriam, Gundlach, Enken, Saleem, Moin A   +8 more
core   +1 more source

Role of Antibody Anti-AGE in the Expression of Nephrin and RAGE on Primary Glomerulus Cell Exposed with AGE

Journal of Tropical Life Science, 2017
Upregulation of nephrin expression occurs at the early stage of nephropathy and decrease in the period 6 months on hyperglycaemic condition. Nephrin is associated with the initial stage of the loss of the permeability barrier in diabetic nephropathy ...
Rudy Salam, Diana Lyrawati, Nur Samsu
doaj   +1 more source

Induced model of nephrin deletion in podocytes.

, 2018
(A) Western blot showing decrease in nephrin in glomerular lysates from Nphs1fl/fl,iCre(ER)T2 mice kidneys 14 weeks post-induction with tamoxifen. Decreasing amounts of lysate volume were loaded in each well to avoid reaching the threshold of the x-ray ...
Rakesh Verma (151646), Ashomathi Mollin (5428904), Theodore Li (5428901), Madhusudan Venkatareddy (192316), Joanna Kukla (5428898), Puneet Garg (192331), Anne Kalinowski (2138212), Gabriel Cara-Fuentes (3949763), Sanjeevkumar R. Patel (238527)   +8 more
core   +1 more source

Nephrin : intracellular trafficking and podocyte maturation

, 2007
Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal recessive disorder caused by mutations in the NPHS1 gene and, consequently, in its product nephrin, a 180 kDa transmembrane protein belonging to the immunoglobulin superfamily of ...
Stefania Cotta Doné (19490482)
core  

Residual nephrin at the membrane is associated with actin.

, 2018
(A) Isolated glomeruli from wild type and Nphs1Tam-Cre mice kidneys were lysed in RIPA buffer containing 1% Triton X-100 at 4°C. Lysates were resolved with SDS-PAGE gel under reducing conditions and probed with nephrin and actin antibodies.
Rakesh Verma (151646), Ashomathi Mollin (5428904), Theodore Li (5428901), Madhusudan Venkatareddy (192316), Joanna Kukla (5428898), Puneet Garg (192331), Anne Kalinowski (2138212), Gabriel Cara-Fuentes (3949763), Sanjeevkumar R. Patel (238527)   +8 more
core   +1 more source

Molecular mechanism of ouabain-induced apoptosis in human podocytes

Linchuang shenzangbing zazhi, 2017
Objective Podocyte apoptosis is involved in lupus nephritis( LN). Endogenous ouabain( EO),one of cardiotonicsteroids( CTS),is markedly up-regulated in chronic kidney disease( CKD) patients and is associated with epithelial-to-mesenchymal transition ...
LOU Mei-yu, LIU Chang-xuan, CHEN Wen-li
doaj  

Nephrin cellular trafficking and intracellular interactions

, 2004
Nephrin is a 180-kDa transmembrane glycoprotein belonging to the immunoglobulin family of cell adhesion molecules. Nephrin has an extracellular part with eight Ig-like motifs, one fibronectin-like domain, a transmembrane region and a short cytoplasmic ...
Xiao Li Liu (9654962)
core