Results 91 to 100 of about 8,883 (209)

Genetic and Iatrogenic Defects in Peripheral Tolerance Associated with Anti-Nephrin Antibody-Associated Minimal Change Disease

Glomerular Diseases
Introduction: Minimal change disease (MCD) is a common cause of nephrotic syndrome in children and adults. Immune dysregulation is a contributor, but the relative roles of individual components of the immune system in MCD pathogenesis remain ...
J. Ashley Jefferson, Karin Chen, Sangeeta Hingorani, A. Bilal Malik, Scott S. Tykodi, Keith H. Keller, Yuan Huang, Kelly D. Smith, Robyn C. Reed, Astrid Weins, Shreeram Akilesh   +10 more
doaj   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Podocytes: recent biomolecular developments

Biomolecular Concepts, 2014
Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. Processes departing from a podocyte interdigitate with corresponding projections from neighboring cells and form an intricate web that enwraps ...
Armelloni Silvia, Corbelli Alessandro, Giardino Laura, Li Min, Ikehata Masami, Mattinzoli Deborah, Messa Piergiorgio, Pignatari Chiara, Watanabe Shojiro, Rastaldi Maria Pia   +9 more
doaj   +1 more source

Nephrin sends us signals [PDF]

Kidney International, 2003
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openaire   +3 more sources

Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells [PDF]

, 2008
In preeclampsia (PE), proteinuria has been associated with a reduced expression of nephrin by podocytes. In the present study, we investigated in vitro on human cultured podocytes the mechanism responsible for nephrin loss in PE.
Camussi G., Bussolati B., Collino, Federica, Camussi, Giovanni, Gerbaudo E., Bussolati, Benedetta, Gerbaudo, Elisa, Pelissetto, Simona, Collino F., Marozio, Luca, Pelissetto S., Marozio L., DI BENEDETTO, CHIARA, Benedetto C.   +13 more
core   +1 more source

Evaluation of methodologies in anti-nephrin autoantibody detection

Kidney International
Recent studies discovered the prominent presence of anti-nephrin autoantibodies in minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). However, widely different and often unconventional autoantibody detection methods were used in these studies, making it challenging to standardize anti-nephrin antibody detection and ...
Pan Liu, Shuping Liu, Vidhi Dalal, Jerome Lane, Paolo Cravedi, Kirk Campbell, Andrea Angeletti, Xinfang Xie, Elisa Gessaroli, Eleonora Forte, Lorenzo Gallon, Jing Jin   +11 more
openaire   +4 more sources

Protective Effects of Physalis angulata on Podocythopathies Through B-Cell-Activating Factor Inhibition in Doxorubicin-Induced Nephrotic Syndrome Rat Model

Biomedicines
Background/Objectives: Nephrotic syndrome, a glomerular disease caused by podocyte dysfunction, is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Astrid K. Kardani, Loeki E. Fitri, Nur Samsu, Krisni Subandiyah   +3 more
doaj   +1 more source

Expression of nephrin by human pancreatic islet endothelial cells

, 2005
Aims/hypothesis: The islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit diaphragm of podocyte foot processes, has been reported in
Zanone, M M, N. Klein, M. Peakman, G. Camussi, Huang, G C, Perin, P C, Deregibus, M C, Greening, J, J. Greening, Favaro, E, E. Favaro, M. C. Deregibus, Peakman, M; id_orcid, S. Doublier, P. Cavallo Perin, G. C. Huang, Camussi, G, B. Lozanoska-Ochser, M. M. Zanone, Lozanoska-Ochser, B, Klein, N, Doublier, S   +21 more
core   +1 more source

Relevance of VEGF and Nephrin Expression in Glomerular Diseases [PDF]

Journal of Signal Transduction, 2011
The glomerular filtration barrier is affected in a large number of acquired and inherited diseases resulting in extensive leakage of plasma albumin and larger proteins, leading to nephrotic syndrome and end-stage renal disease. Unfortunately, the molecular mechanisms governing the development of the nephrotic syndrome remain poorly understood.
openaire   +2 more sources

Nicotine decrease nephrin expression in podocyte.

, 2016
Differentiated human podocytes were treated with nicotine (1 and10 μM) for 48 h. Cell lysates were then collected and subjected for Western blotting to detect nephrin expression. A. Representative gels are displayed. B.
Pravin C. Singhal (335757), Judith M. Eng (3373799), Seyedeh Shadafarin Marashi Shoshtari (3373796), Xiqian Lan (219539), Ashwani Malhotra (335756), Rivka Lederman (396526), Moin A. Saleem (162077)   +6 more
core   +1 more source