Results 71 to 80 of about 8,883 (209)

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells

Scientific Reports, 2021
Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Tomoko Ohmori, Shankhajit De, Shunsuke Tanigawa, Koichiro Miike, Mazharul Islam, Minami Soga, Takumi Era, Shinichi Shiona, Koichi Nakanishi, Hitoshi Nakazato, Ryuichi Nishinakamura   +10 more
doaj   +1 more source

Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization [PDF]

Journal of Clinical Investigation, 2006
A properly established and maintained podocyte intercellular junction, or slit diaphragm, is a necessary component of the selective permeability barrier of the kidney glomerulus. The observation that mutation or deletion of the slit diaphragm transmembrane protein nephrin results in failure of podocyte foot process morphogenesis and concomitant ...
Rakesh, Verma, Iulia, Kovari, Abdul, Soofi, Deepak, Nihalani, Kevin, Patrie, Lawrence B, Holzman   +5 more
openaire   +2 more sources

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes

, 2008
Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases.
Aoudjit, L., Zhu, J., Takano, T., Lemay, S., Li, H., Kawachi, H., Sun, N.   +6 more
core   +1 more source

Renal Implications of Psoriasis: Urinary Podocyte Markers and Disease Progression

Dermatology Practical & Conceptual
Introduction: Psoriasis may lead to glomerular inflammatory damage and disruption of the podocyte barrier, allowing podocyte degradation products to leak into the urine.
Sule Gencoglu, Meltem Yardim, Ramazan Fazil Akkoc   +2 more
doaj   +1 more source

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Stem Cell Reports, 2018
Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Shunsuke Tanigawa, Mazharul Islam, Sazia Sharmin, Hidekazu Naganuma, Yasuhiro Yoshimura, Fahim Haque, Takumi Era, Hitoshi Nakazato, Koichi Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Hidetake Kurihara, Atsuhiro Taguchi, Ryuichi Nishinakamura   +13 more
doaj   +1 more source

APOL1 and nephrin expression in kidney biopsies.

, 2016
Tissue sections of biopsies of patients suffering from membranous glomerulonephritis (MGN) and focal segmental glomerulosclerosis (FSGS) stained with antibodies against APOL1 and nephrin showed a marked decrease of APOL1 (A, I) as well as nephrin (B, J ...
Uwe Zimmermann (214606), Ahmed M. Kotb (2637514), Frank Dombrowski (2637508), Karlhans Endlich (112716), Antje Blumenthal (112861), Silke Vogelgesang (2637511), Ole Simon (2637517), Nicole Endlich (170572), Kerstin Amann (186160)   +8 more
core   +1 more source

Podocin Regulates the Nephrin-Nephrin Distance in the Glomerular Pore [PDF]

Biophysical Journal, 2020
Gusztav Schay, Violetta Antal, Máté Kétszeri, Katalin Csókay, Miklós S. Kellermayer, Dóra Karancsiné Menyhárd, Kálmán Tory   +6 more
openaire   +1 more source

Study of the role of nephrin and nephrin-related proteins in signaling and physiology of pancreatic beta-cells

, 2015
In this study, we investigated the potential role of nephrin in the regulation of pancreatic beta cell survival. We utilized endogenous nephrin expression in βTC-6 cells and demonstrated that nephrin was associated and co-localized with PI3K in both ...
Καποδίστρια, Αικατερίνη, Kapodistria, Aikaterini   +1 more
core   +1 more source

Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release

, 2010
Nephrin, an immunoglobulin-like protein essential for the function of the glomerular podocyte and regulated in diabetic nephropathy, is also expressed in pancreatic beta-cells, where its function remains unknown.
Cobianchi, Lorenzo, Reiser, Jochen, Jeon, Jongmin, Varona Santos, Javier, Mandic, Slavena A, Kerjaschki, Dontscho, Inverardi, Luca, Jauregui, Alexandra, Berggren, Per-Olof, Mundel, Peter, Johnson, Kevin, Molano, R Damaris, Ricordi, Camillo, Bark, Christina, Pileggi, Antonello, McNamara, George, Tryggvason, Karl, Fornoni, Alessia   +17 more
core   +2 more sources