Results 61 to 70 of about 8,883 (209)

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome. [PDF]

PLoS ONE, 2015
The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB).
Haiyan Wang, Zhihui Yue, Jinlang Wu, Ting Liu, Ying Mo, Xiaoyun Jiang, Liangzhong Sun   +6 more
doaj   +1 more source

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

Conditional deletion of nephrin in podocytes.

, 2018
(A) Schematic of the targeting vector containing a neomycin cassette, Frt sites and loxP sites were engineered to flank exon 5 of mouse nephrin. Successful recombination was verified using Southern blot with probes 1 and 2 flanking the nephrin gene.
Rakesh Verma (151646), Ashomathi Mollin (5428904), Theodore Li (5428901), Madhusudan Venkatareddy (192316), Joanna Kukla (5428898), Puneet Garg (192331), Anne Kalinowski (2138212), Gabriel Cara-Fuentes (3949763), Sanjeevkumar R. Patel (238527)   +8 more
core   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley, Tatsuya Sueyoshi, Sivapriya Ramamoorthy, Viktoriya D. Nikolova, David R. Goulding, Jianying Li, Manas K. Ray, Sheryl S. Moy, John A. Cidlowski   +8 more
wiley   +1 more source

Reduced nephrin tyrosine phosphorylation with A419T and C623F mutations.

, 2018
(A) HEK293T cells were transfected with Myc-tagged nephrin variants, alone or in combination, and lysates were immunoblotted (IB) as indicated with antibodies to nephrin, total phosphotyrosine (pY) or site-specific phosphorylated nephrin (pY1176 or ...
Claire E. Martin (5746709), Paul S. Thorner (5746715), C. James Cooper (5746703), Nikkita T. Dutta (5746706), Tino D. Piscione (5746712), Nina Jones (5746718)   +5 more
core   +1 more source

Nephrin as a biomarker of sickle cell glomerulopathy in Malawi [PDF]

Pediatric Blood & Cancer, 2018
AbstractBackgroundGlomerulopathy is an increasingly identified complication in young patients with sickle cell disease (SCD). Hyperfiltration and albuminuria followed by declining glomerular filtration rates and eventual end‐stage renal disease (ESRD) is assumed to be the typical progression of glomerular disease.
J. Brett Heimlich, Godwin Chipoka, Laila Elsherif, Emeraghi David, Graham Ellis, Portia Kamthunzi, Robert Krysiak, Pilirani Mafunga, Qingning Zhou, Jianwen Cai, Satish Gopal, Nigel S. Key, Kenneth I. Ataga   +12 more
openaire   +2 more sources

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Deletion of nephrin in adult mature glomerulus.

, 2018
(A) Immunofluorescence images showing nephrin and synaptopodin staining at 2 weeks following Cre-induction with tamoxifen. There is abrogation of peri-nuclear nephrin staining following induction (arrowheads).
Rakesh Verma (151646), Ashomathi Mollin (5428904), Theodore Li (5428901), Madhusudan Venkatareddy (192316), Joanna Kukla (5428898), Puneet Garg (192331), Anne Kalinowski (2138212), Gabriel Cara-Fuentes (3949763), Sanjeevkumar R. Patel (238527)   +8 more
core   +1 more source

Afucosylated IgG in idiopathic nephrotic syndrome patients with anti-nephrin autoantibodies correlate with disease activity

Journal of Translational Autoimmunity
Background: Idiopathic nephrotic syndrome (INS) is a glomerular disorder characterized by podocyte injury and proteinuria. Emerging evidence suggests that anti-nephrin autoantibodies (Abs) may contribute to disease pathogenesis in a subset of INS ...
Sonia Spinelli, Andrea Garbarino, Francesca Lugani, Edoardo La Porta, Noemi Rumeo, Giorgio Piaggio, Alberto Magnasco, Antonella Trivelli, Maria Ludovica Degl’Innocenti, Gino Tripodi, Simona Granata, Francesca Leone, Elena Zocchi, Lorenzo Gallon, Gian Marco Ghiggeri, Enrico Verrina, Gianluigi Zaza, Giovanni Candiano, Maurizio Bruschi   +18 more
doaj   +1 more source