Results 191 to 200 of about 12,065 (211)
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Nephrin and endothelial injury
Current Opinion in Nephrology & Hypertension, 2009Nephrin, the main structural protein of the slit diaphragm, is expressed on the surface of glomerular podocytes and is critical in maintaining permselectivity and preventing proteinuria. This review focuses on the fate of nephrin in the context of endothelial injury and gives an update on the recent progress in understanding the pathomechanisms that ...
Hauser PV +3 more
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Monoclonal Antibodies to Human Nephrin
Hybridoma and Hybridomics, 2004Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Vesa, Ruotsalainen +4 more
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Nephrin in human lymphoid tissues
Cellular and Molecular Life Sciences CMLS, 2006When nephrin, the protein product of NPHS1, was cloned, it was proposed to be specific for the kidney glomerular podocytes. Recently, however, new reports have emerged verifying additional nephrin expression sites, particularly the insulin-producing beta cells of the pancreas, as well as the central nervous system. In this study, we demonstrate nephrin
E, Aström +6 more
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Autoantibodies Targeting Nephrin in Podocytopathies
New England Journal of MedicineMinimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome in children, are immune-mediated podocytopathies that lead to nephrotic syndrome. Autoantibodies targeting nephrin have been found in patients with minimal change disease, but their clinical and pathophysiological roles are unclear ...
Bruschi M., Angeletti A., Ghiggeri G. M.
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mAb 5‐1‐6 nephropathy and nephrin
Microscopy Research and Technique, 2002AbstractIt is well established that the glomerular capillary wall consists of three layers: endothelial cell, glomerular basement membrane, and the slit diaphragm bridging foot processes of glomerular epithelial cell. Which structure in the glomerular capillary wall represents the primary filter for retaining plasma proteins is not clearly elucidated ...
Hiroshi, Kawachi +2 more
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Nephrin—signature molecule of the glomerular podocyte?
The Journal of Pathology, 2009AbstractIn recent years there has been an explosion of interest in the glomerular podocyte, which plays a central role in control of glomerular filtration. A host of new molecules have been identified as playing essential roles in the maintenance of podocyte integrity in both humans and mouse models.
Welsh, G, Saleem, MA
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Phosphorylation status of nephrin in human membranous nephropathy
Clinical and Experimental Nephrology, 2009We recently reported that nephrin, a major slit-diaphragm protein, is phosphorylated at Y1204 and Y1228 in normal human glomeruli and that phosphorylation decreased significantly in minimal-change nephrosis. These results indicate that phosphorylation of nephrin is important for maintenance of normal podocyte morphology and function. On the other hand,
Teiko, Ohashi +6 more
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Nephrin mRNA regulation by protein kinase C.
Journal of nephrology, 2001Mutations in the recently cloned NPHS1 gene result in congenital nephrotic syndrome of the Finnish type (CNF). The protein product of NPHS1, nephrin, is expressed uniquely in kidney glomerular podocytes, and is the first true component of the interpodocyte slit membrane.
WANG S. X., MENE', Paolo, HOLTHOFER H.
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Reactome - a curated knowledgebase of biological pathways, 2010
F Grahammer, T Huber
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F Grahammer, T Huber
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