Results 191 to 200 of about 12,068 (208)

Autoantibodies Targeting Nephrin in Podocytopathies

New England Journal of Medicine
Minimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome in children, are immune-mediated podocytopathies that lead to nephrotic syndrome. Autoantibodies targeting nephrin have been found in patients with minimal change disease, but their clinical and pathophysiological roles are unclear ...
Bruschi M., Angeletti A., Ghiggeri G. M.
openaire   +9 more sources

mAb 5‐1‐6 nephropathy and nephrin

Microscopy Research and Technique, 2002
AbstractIt is well established that the glomerular capillary wall consists of three layers: endothelial cell, glomerular basement membrane, and the slit diaphragm bridging foot processes of glomerular epithelial cell. Which structure in the glomerular capillary wall represents the primary filter for retaining plasma proteins is not clearly elucidated ...
Hiroshi, Kawachi, Hiroko, Koike, Fujio, Shimizu   +2 more
openaire   +2 more sources

Nephrin—signature molecule of the glomerular podocyte?

The Journal of Pathology, 2009
AbstractIn recent years there has been an explosion of interest in the glomerular podocyte, which plays a central role in control of glomerular filtration. A host of new molecules have been identified as playing essential roles in the maintenance of podocyte integrity in both humans and mouse models.
Welsh, G, Saleem, MA
openaire   +3 more sources

Phosphorylation status of nephrin in human membranous nephropathy

Clinical and Experimental Nephrology, 2009
We recently reported that nephrin, a major slit-diaphragm protein, is phosphorylated at Y1204 and Y1228 in normal human glomeruli and that phosphorylation decreased significantly in minimal-change nephrosis. These results indicate that phosphorylation of nephrin is important for maintenance of normal podocyte morphology and function. On the other hand,
Teiko, Ohashi, Keiko, Uchida, Yukari, Asamiya, Yuki, Tsuruta, Mayuko, Ohno, Shigeru, Horita, Kosaku, Nitta   +6 more
openaire   +2 more sources

Nephrin mRNA regulation by protein kinase C.

Journal of nephrology, 2001
Mutations in the recently cloned NPHS1 gene result in congenital nephrotic syndrome of the Finnish type (CNF). The protein product of NPHS1, nephrin, is expressed uniquely in kidney glomerular podocytes, and is the first true component of the interpodocyte slit membrane.
WANG S. X., MENE', Paolo, HOLTHOFER H.
openaire   +2 more sources

ER-associated degradation of nephrin

Nature Reviews Nephrology, 2021
openaire   +2 more sources

Nephrin interactions

Reactome - a curated knowledgebase of biological pathways, 2010
F Grahammer, T Huber
openaire   +1 more source

Nephrin

Journal of Hypertension, 2003
openaire   +1 more source

NEUROTIC SYMPTOMS AND EPI-NEPHRINE

The Journal of Nervous and Mental Disease, 1943
S. H. Kraines, Irene C. Sherman
openaire   +1 more source

Role of nephrin in proteinuric renal diseases

Springer Seminars in Immunopathology, 2003
David J, Salant, Peter S, Topham
openaire   +2 more sources