Creating realistic nerve agent victim profiles for computer simulation of medical CBRN disaster response [PDF]
Frontiers in Public Health, 2023 In the last decades, Chemical, Biological, Radiological and Nuclear (CBRN) threats have become serious risks prompting countries to prioritize preparedness for such incidents.
Ruben De Rouck +7 more
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ON GOLD AS A STAINING AGENT FOR NERVE TISSUES [PDF]
The Journal of Nervous and Mental Disease, 1888 n ...
HENRY S. UPSON
openalex +7 more sources
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]
PLoS ONE, 2011 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert +14 more
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Qualitative Analysis of Novel Flavonoid Adducts from Nerve Agent Tabun-Exposed Arabidopsis thaliana (L.) Based on Quadrupole–Time of Flight Mass Spectrometry [PDF]
Molecules, 2023 Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers.
Zhongfang Xing +8 more
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Chromogenic detection of nerve agent mimics [PDF]
Chemical Communications, 2008 A new chromogenic protocol for the selective detection of nerve agent mimics is reported.Costero Nieto, Ana Maria, Ana.Costero@uv.es ; Gil Grau, Salvador, Salvador.Gil@uv.es ; Parra Alvarez, Margarita, Margarita.Parra@uv ...
Ana M. Costero +39 more
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Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent [PDF]
Frontiers in Cellular NeuroscienceOrganophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that
Chandrakumar Bogguri +10 more
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Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines [PDF]
Frontiers in Neuroscience, 2021 Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan +11 more
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Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX) [PDF]
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
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LABORATORY EXAMINATION IN NERVE AGENT INTOXICATION [PDF]
Acta Medica, 2013 Diagnosis of nerve agent intoxication is based on anamnestic data, clinical signs and laboratory examination. For acute poisoning, cholinesterase activity in the blood (erythrocyte AChE, plasma/serum BuChE) is sensitive, simple and most frequent ...
Jiří Bajgar
doaj +4 more sources
Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase [PDF]
Communications Biology, 2021 Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified ...
Gabriel Amitai +10 more
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