Creating realistic nerve agent victim profiles for computer simulation of medical CBRN disaster response [PDF]
Frontiers in Public Health, 2023 In the last decades, Chemical, Biological, Radiological and Nuclear (CBRN) threats have become serious risks prompting countries to prioritize preparedness for such incidents.
Ruben De Rouck +7 more
doaj +4 more sources
Qualitative Analysis of Novel Flavonoid Adducts from Nerve Agent Tabun-Exposed Arabidopsis thaliana (L.) Based on Quadrupole–Time of Flight Mass Spectrometry [PDF]
Molecules, 2023 Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers.
Zhongfang Xing +8 more
doaj +2 more sources
Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent [PDF]
Frontiers in Cellular NeuroscienceOrganophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that
Chandrakumar Bogguri +10 more
doaj +2 more sources
Military Medicine, 2023 Observations of military conflicts and local wars of recent decades show us that the concept of "chemical weapons" has not yet been deleted from the military lexicon of various countries, despite the convention on its prohibition. In recent decades, there have been cases of the use of mustard gas, sarin, tabun and VX in Halabaja (Iraq), sarin in Tokyo (
А. А. Бова +5 more
openalex +2 more sources
Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase [PDF]
Communications Biology, 2021 Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified ...
Gabriel Amitai +10 more
doaj +3 more sources
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin [PDF]
Journal of Neuroinflammation, 2011 Background Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well ...
Meyerhoff James L +4 more
doaj +2 more sources
A Novel Organophosphorus Acid Anhydrolase from Deep Sea Sediment with High Degradation Efficiency for Organophosphorus Pesticides and Nerve Agent. [PDF]
Microorganisms, 2022 Zheng X, Wang L, Qi L, Dong Z.
europepmc +3 more sources
A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic. [PDF]
Molecules, 2022 Guo X, Liu CX, Lu Y, Wang YW, Peng Y.
europepmc +3 more sources
Synthesis and characterization of nitrogen-doped-MWCNT@cobalt oxide for nerve agent simulant detection. [PDF]
Sci RepLama S +4 more
europepmc +3 more sources
N-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats. [PDF]
Toxicol Res (Camb)Shri P +5 more
europepmc +3 more sources