Results 11 to 20 of about 349,810 (341)

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +14 more sources

Development of Nano Ache Enzyme Based Sensor for Determination of Nerve Agents Used in Chemical Weapons [PDF]

Gazi Üniversitesi Fen Bilimleri Dergisi, 2020
In this study; Nano enzyme system based sensor system has been developed for detection of nerve agents used in chemical weapons production. The chemical substances forming the nerve agents are included in the group of organophosphorus compounds. Paraoxon
Ozan YAĞMUROĞLU, Sibel Emir DİLTEMİZ
doaj   +1 more source

Leveraging Dissolution by Autoinjector Designs

Pharmaceutics, 2022
Chemical warfare or terrorism attacks with organophosphates may place intoxicated subjects under immediate life-threatening and psychologically demanding conditions.
Christoph Spangardt, Christoph Keßler, Ramona Dobrzewski, Antonia Tepler, Simon Hanio, Bernd Klaubert, Lorenz Meinel   +6 more
doaj   +1 more source

Thermocatalytic Decomposition of Dimethyl Methylphosphonate Based on CeO₂ Catalysts with Different Morphologies

Applied Sciences, 2023
The catalytic performances of the catalysts and decomposition mechanisms of dimethyl methylphosphonate (DMMP), a commonly used nerve agent simulant, are well understood based on previous studies.
Weimin Kong, Xuwei Wang, Kunpeng Wang, Qingrong He, Shuyuan Zhou, Piaoping Yang, Yanchun Dong   +6 more
doaj   +1 more source

UiO-66-NH₂ and Zeolite-Templated Carbon Composites for the Degradation and Adsorption of Nerve Agents

Molecules, 2021
Composites of metal-organic frameworks and carbon materials have been suggested to be effective materials for the decomposition of chemical warfare agents.
Jaeheon Lee, Dongwon Ka, Heesoo Jung, Kyeongmin Cho, Youngho Jin, Minkun Kim   +5 more
doaj   +1 more source

Theoretical study of the molecular aspect of the suspected novichok agent A234 of the Skripal poisoning [PDF]

Royal Society Open Science, 2019
Novichoks are the suspected nerve agents in the March 2018 Skripal poisoning. In this context, the novichok agent A234 (chemical structure proposed by Mirzayanov) was studied using computational methods to shed light on its molecular, electronic ...
Hanusha Bhakhoa, Lydia Rhyman, Ponnadurai Ramasami   +2 more
doaj   +1 more source

Nerve agents: emergency preparedness [PDF]

BMJ Military Health, 2020
Nerve agents (NAs) are a highly toxic group of chemical warfare agents. NAs are organophosphorus esters with varying physical and chemical properties depending on the individual agent. The most recently developed class of NA is‘Novichok’, the existence of which was first revealed in the early 1990s, just before Russia signed the Chemical Weapons ...
Alan George Andrew Weir, S Makin, J Breeze   +2 more
openaire   +2 more sources

Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines

Frontiers in Neuroscience, 2021
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren   +11 more
doaj   +1 more source

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, 2023
Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
doaj   +1 more source

Thermal Catalytic Decomposition of Dimethyl Methyl Phosphonate Using CuO-CeO₂/γ-Al₂O₃

Applied Sciences, 2022
Chemical warfare agents (CWAs) are highly toxic and fast-acting and are easy to cause large-scale poisoning to humans and livestock after being released. The activated carbon used for CWAs adsorption has disadvantages of limited adsorption capacity, easy
Han Gao, Weimin Kong, Shuyuan Zhou, Xuwei Wang, Qingrong He, Yanchun Dong   +5 more
doaj   +1 more source