Results 21 to 30 of about 4,230,808 (299)

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, 2023
Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
doaj   +1 more source

Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines

Frontiers in Neuroscience, 2021
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren   +11 more
doaj   +1 more source

Heterometallic Titanium-Organic Frameworks as Dual Metal Catalysts for Synergistic Non-Buffered Hydrolysis of Nerve Agent Simulants

Chem, 2020
Summary Mixed-metal or heterometallic metal-organic frameworks (MOFs) are gaining importance as a route to produce materials with increasing chemical and functional complexities.
J. Castells‐Gil, Natalia M. Padial, Neyvis Almora‐Barrios, R. Gil-San-Millan, María Romero-Angel, V. Torres, Iván da Silva, J. Waerenborgh, Jaciek Jagiello, J. Navarro, S. Tatay, Carlos Martí‐Gastaldo   +11 more
semanticscholar   +1 more source

Theoretical study on the toxicity of ‘Novichok’ agent candidates [PDF]

Royal Society Open Science, 2019
The identities and properties of ‘Novichok’ (Russian for ‘newcomer’ or ‘novice’) agents allegedly used in the recent terrorist attack in the UK have not been well documented. Although several people previously involved in the synthesis of these materials
Keunhong Jeong, Junwon Choi
doaj   +1 more source

Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma

Molecules, 2021
To identify biomarkers of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)- or methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A232)-inhibited butyrylcholinesterase (BChE), we investigated nonapeptide adducts containing the ...
Woo-Hyeon Jeong, Jin-Young Lee, Kyoung-Chan Lim, Hyun-Suk Kim   +3 more
doaj   +1 more source

Thermal Catalytic Decomposition of Dimethyl Methyl Phosphonate Using CuO-CeO₂/γ-Al₂O₃

Applied Sciences, 2022
Chemical warfare agents (CWAs) are highly toxic and fast-acting and are easy to cause large-scale poisoning to humans and livestock after being released. The activated carbon used for CWAs adsorption has disadvantages of limited adsorption capacity, easy
Han Gao, Weimin Kong, Shuyuan Zhou, Xuwei Wang, Qingrong He, Yanchun Dong   +5 more
doaj   +1 more source

Catalytic Degradation of Nerve Agents [PDF]

Catalysts, 2020
Nerve agents (NAs) are a group of highly toxic organophosphorus compounds developed before World War II. They are related to organophosphorus pesticides, although they have much higher human acute toxicity than commonly used pesticides. After the detection of the presence of NAs, the critical step is the fast decontamination of the environment in order
Zammataro, Agatino, Santonocito, Rossella, Pappalardo, Andrea, Trusso Sfrazzetto, Giuseppe   +3 more
openaire   +2 more sources

Ethanol Ablation of a Peripheral Nerve Sheath Tumor Presenting as a Small Bowel Obstruction. [PDF]

, 2015
Ethanol has historically been used as an ablative agent for a variety of lesions. One of the more common applications of this technique is celiac plexus neurolysis; however, recent reports have suggested a role for the endoscopic alcohol ablation of a ...
Chang, Kenneth, Chen, Chien-Lin, Chin, Matthew, Lee, John, Samarasena, Jason   +4 more
core   +1 more source

Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology

Frontiers in Cellular Neuroscience, 2022
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel
Meghan Gage, Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy, Thimmasettappa Thippeswamy   +10 more
doaj   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Nordmann, J. J., Weller, U.   +4 more
core   +1 more source