Retinal and optic nerve degeneration in liver X receptor β knockout mice. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Optic neuritis, an inflammatory disease of the optic nerve, leads to death of retinal ganglion cells (RGC) and impaired vision. Both LXRα and LXRβ are expressed in the retina and optic nerve.
Song XY +8 more
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Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
Nature Communications, 2016 Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic ...
Feng Tian +20 more
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Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration. [PDF]
Sci Rep, 2019 Potential mechanisms involved in neural differentiation of adipocyte derived stem cells (ADSCs) are still unclear. In the present study, extracellular vesicles (EVs) were tested as a potential mechanism involved in the neuronal differentiation of stem ...
Roballo KCS +11 more
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Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress. [PDF]
ASN Neuro, 2019 During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells.
Kim M +8 more
europepmc +2 more sources
Retinal and optic nerve degeneration in α-mannosidosis. [PDF]
Orphanet J Rare Dis, 2018 Backgroundα-mannosidosis is a rare, autosomal-recessive, lysosomal storage disease caused by a deficient activity of α-mannosidase. Typical symptoms include intellectual, motor and hearing impairment, facial coarsening, and musculoskeletal abnormalities.
Matlach J +5 more
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Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration [PDF]
Cell Death and Disease, 2013 Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies demonstrated the crucial role of nicotinamide mononucleotide adenylyltransferase (Nmnat) 1, 2, and 3 in axonal protection.
Yasushi Kitaoka +5 more
openalex +2 more sources
PGC-1α Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1. [PDF]
Cell Mol Neurobiol, 2023 Zou Y, Wu S, Wen F, Ge Y, Luo S.
europepmc +3 more sources
Frontiers in Cellular Neuroscience, 2016 Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury.
Jun Yu, Xiaosong Gu, Sheng Yi
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Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model. [PDF]
Front Cell Neurosci, 2017 Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion.
Renner M +8 more
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The chemistry of nerve-degeneration [PDF]
Proceedings of the Royal Society of London, 1901 We have previously shown that in the disease, General Paralysis of the Insane, the marked degeneration that occurs in the brain is accompanied by the passing of the products of degeneration into the cerebro-spinal fluid. Of these, nucleo-proteid and choline are those which can be most readily detected. Choline can also be found in the blood.
F. Mott, W. D. Halliburton
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