CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]
, 2017 The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian +17 more
core +1 more source
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]
, 2004 Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Anderson, PN +6 more
core +3 more sources
Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]
Scientific Reports 4, 5430 (2014), 2013 Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv +1 more source
Epigenetics in glaucoma: a link between histone methylation and neurodegeneration
The Journal of Clinical Investigation, 2023 Normal-tension glaucoma is a form of optic nerve degeneration that is characterized by loss of retinal ganglion cells independent of eye pressure elevation. In this issue of the JCI, Pan et al.
Wendy W. Liu, Yang Sun
doaj +1 more source
CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice
Cell Death and Disease, 2021 Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive optic nerve degeneration and retinal ganglion cell loss.
Meng Ye +11 more
doaj +1 more source
Cells, 2021 Unraveling the cellular and molecular mechanisms of spinal cord injury is fundamental for our possibility to develop successful therapeutic approaches.
Håkan Aldskogius, Elena N. Kozlova
doaj +1 more source
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]
, 2012 Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C. +7 more
core +2 more sources
Critical signaling pathways during Wallerian degeneration of peripheral nerve
Neural Regeneration Research, 2017 Wallerian degeneration is a critical biological process that occurs in distal nerve stumps after nerve injury. To systematically investigate molecular changes underlying Wallerian degeneration, we used a rat sciatic nerve transection model to examine ...
Qiong Cheng +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Wallerian degeneration (WD) is associated with changes in the expression levels of a large number of genes. However, the effects of these up- or down-regulated genes are poorly understood.
Yuting Li +7 more
semanticscholar +1 more source
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]
, 2012 The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Arthur-Farraj, PJ +16 more
core +1 more source