Results 1 to 10 of about 656,709 (237)

Nerve Growth Factor and Autoimmune Diseases. [PDF]

Curr Issues Mol Biol, 2023
NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and ...
Terracina S, Ferraguti G, Tarani L, Fanfarillo F, Tirassa P, Ralli M, Iannella G, Polimeni A, Lucarelli M, Greco A, Fiore M.   +10 more
europepmc   +2 more sources

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato, Giovanni Galasso, Pia Giovannelli, Antonio A. Sinisi, Antimo Migliaccio, Gabriella Castoria   +5 more
doaj   +4 more sources

Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19. [PDF]

Biology (Basel)
Neurotrophins (NTs) constitute a family of small protein messengers that play a fundamental role in both the central and peripheral nervous systems. In particular, the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF) play a ...
Petrella C, Ferraguti G, Tarani L, Tarani F, Messina MP, Fiore M.   +5 more
europepmc   +2 more sources

The statistical mechanics of complex signaling networks : nerve growth factor signaling [PDF]

, 2004
It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort is being made to experimentally measure the rate constants for individual steps in these signaling networks, many
Arkin A, Brown K S, Brown K S Sethna J P, Chen K C, Fletcher R, Goldbeter A, Greene L A, Hastings W K, Kirkpatrick S, Laub M T, Marquardt D W, Metropolis N, Newman M E J, Press W H, Robert C P, Stryer L, Traverse S   +16 more
arxiv   +3 more sources

Multifaceted Roles of Nerve Growth Factor: A Comprehensive Review with a Special Insight into Pediatric Perspectives. [PDF]

Biology (Basel)
Nerve growth factor (NGF) is a neurotrophic peptide largely revealed for its ability to regulate the growth and survival of peripheral sensory, sympathetic, and central cholinergic neurons.
Capossela L, Gatto A, Ferretti S, Di Sarno L, Graglia B, Massese M, Soligo M, Chiaretti A.   +7 more
europepmc   +2 more sources

Prediction of relative change in free nerve growth factor following subcutaneous administration of tanezumab, a novel monoclonal antibody to nerve growth factor. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Tanezumab is a monoclonal antibody against nerve growth factor (NGF). We investigated tanezumab pharmacokinetic (PK)‐NGF relationships and predicted the extent of systemic free NGF suppression with target‐mediated drug disposition (TMDD) modeling using ...
Shoji S, Suzuki A, Nouri P, Cai CH, Gaitonde P, Marshall S.   +5 more
europepmc   +2 more sources

Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

Cell Communication and Signaling, 2022
Plain English summary Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells ...
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri   +3 more
doaj   +1 more source

Topical delivery of nerve growth factor for treatment of ocular and brain disorders

Neural Regeneration Research, 2021
Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity.
Gemma Eftimiadi, Marzia Soligo, Luigi Manni, Daniela Di Giuda, Maria Lucia Calcagni, Antonio Chiaretti   +5 more
doaj   +1 more source

Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. [PDF]

PLoS ONE, 2013
Nerve growth factor is a neurotrophin that promotes cell growth, differentiation, survival and death through two different receptors: TrkA(NTR) and p75(NTR).
Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofiglio   +8 more
doaj   +1 more source

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
doaj   +1 more source