Results 71 to 80 of about 1,563,345 (405)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury

Stem cell research & therapeutics, 2020
The development of new treatment strategies to improve peripheral nerve repair after injury, especially those that accelerate axonal nerve regeneration, is very important.
Jiuhong Zhao, Yali Ding, Rui He, Kui Huang, Lucinda S Liu, Chaona Jiang, Zhuozhou Liu, Yuanlan Wang, Xiaokai Yan, Fuyang Cao, Xueying Huang, Yanan Peng, Rui Ren, Yuebin He, Tian-wei Cui, Quanpeng Zhang, Xianfang Zhang, Qibing Liu, YunQing Li, Zhijian Ma, Xinan Yi   +20 more
semanticscholar   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Nerve trunk healing and neuroma formation after nerve transection injury

Frontiers in Neurology, 2023
The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At
Dong-Xu Huang, Ming-Xi Yang, Zhen-Min Jiang, Miao Chen, Kun Chang, Yong-Xin Zhan, Xu Gong   +6 more
doaj   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used.
Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira   +5 more
doaj   +1 more source

TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling [PDF]

, 2018
Preconditioning nerve injuries activate a pro-regenerative program that enhances axon regeneration for most classes of sensory neurons. However, nociceptive sensory neurons and central nervous system neurons regenerate poorly.
DiAntonio, Aaron, Frey, Erin, Karney-Grobe, Scott, Krolak, Trevor, Milbrandt, Jeff   +4 more
core   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]

, 2019
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu, Huang, Ching-Wen, Huang, Wen-Chin, Li, Song, Patel, Shyam   +4 more
core  

The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]

, 2013
Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E., Furukawa, Koichi, Rupp, Angie, Willison, Hugh J., Yao, Denggao   +4 more
core   +1 more source