Results 101 to 110 of about 100,489 (216)

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Phytotherapy Research, EarlyView.
Leonurine inhibits PKM2 to remodel hepatocyte glycolysis, thereby alleviating liver injury in alcoholic hepatitis. ABSTRACT Alcoholic hepatitis (AH) is a liver disease caused by long‐term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis.
Xuan‐Xuan Zhang, Gao‐Feng Pan, Hong Fang, Xiao‐Peng Liu, Jing Sun, Ji‐Xiang Chen, Xin Fan, Jia‐Hao Feng   +7 more
wiley   +1 more source

Scale‐dependent pathways from land use to fish diversity: eDNA analysis reveals water quality as key mediator in the Nanliu River Basin

River, EarlyView.
Abstract Human‐induced land‐use change poses substantial risks to aquatic biodiversity; however, the multi‐scale pathways linking land‐use patterns to fish diversity remain insufficiently resolved. Focusing on the Nanliu River Basin (Guangxi, China), we integrated environmental DNA (eDNA) detection with partial least squares structural equation ...
Zhipeng Li, Yang Ding, Yinjun Zhao, Jinyong Zhao, Zicheng Yu, Liangshuo Ren, Yanyan Li   +6 more
wiley   +1 more source

Microbiota as the candidate biomarker in pediatric obstructive sleep apnea

Sleep Research, EarlyView.
Abstract Pediatric obstructive sleep apnea (OSA) is a form of sleep‐disordered breathing in children. Recent studies have focused on characterizing microbiota alterations associated with pediatric OSA and identifying microbial features that may have potential value as future biomarkers. The most commonly used approach for microbiota profiling is second‐
Xiaoyan Li, Jingxuan Bai, Ying Xu, Min Yu, Xuemei Gao   +4 more
wiley   +1 more source

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

Small, EarlyView.
Structure‐guided internal twin‐Strep tagging of the tetraspanins CD63 or CD9 enables rapid and efficient antibody‐free affinity isolation of engineered extracellular vesicles (EVs) using Strep technology while allowing luminal protein loading. The approach removes over 96% of contaminants, separates tagged EVs from coexisting viral particles, and ...
Minh‐Tu Pham, Jona Benjamin Krohn, Janis Meyer, Christian Ritter, Martin Schneider, Dominic Helm, Dario Frey, Kleopatra Rapti, Uta Haselmann‐Weiss, Elif Toprak, Viet Loan Dao Thi, Florian Leuschner, Dirk Grimm, Karl Rohr, Ralf Bartenschlager   +14 more
wiley   +1 more source

Husbandry factors are associated with skin, gastrointestinal and ophthalmic disorders in leopard geckos (Eublepharis macularius)

Veterinary Record, EarlyView.
Abstract Background Research into disorders in captive reptiles is notably sparse in the UK, despite the popularity of various species as pets. This study aimed to survey and investigate risk factors for disorders of leopard geckos in the UK. Methods Medical records for leopard geckos presenting at three veterinary practices between 2019 and 2023 were ...
Joshua Henley, Tom Dutton, Joanna Hedley
wiley   +1 more source

A Single-Tube Nested PCR Method for <i>SMN1</i> Deletion Detection in Spinal Muscular Atrophy. [PDF]

Methods Protoc
Kosaka A, Sakima M, Noguchi Y, Shiroshita T, Aoki Y, Otsuka Y, Bouike Y, Nishio H.   +7 more
europepmc   +1 more source

Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China. [PDF]

Front Microbiol, 2023
Wu Z, Li N, Li Z, Wang J, Liu M, Qi M, Wei S, Wu T, Guo Y, Zhu J, Jiang H, Xue R, Sun C, Feng X, Gu J, Han W, Li F, Lei L.   +17 more
europepmc   +1 more source

Porcine circovirus 2 vaccination timing was not associated with piglets’ serological response

Veterinary Record, EarlyView.
Abstract Background The development of immunity in pigs starts in utero, but piglets are born immunologically immature and rely on maternal antibodies. Weaning exposes piglets to multiple stressors, yet vaccination is commonly performed around weaning.
Lea Uotinen, Sanna Nikunen, Gitte Blach Nielsen, Mari Heinonen   +3 more
wiley   +1 more source

Pan filarial-nested PCR with gelified tubes: a new approach towards point-of-care testing for human filariasisFIRST REVIEW ROUND - REVIEWERS' COMMENTSREVIEWERS' COMMENTS. [PDF]

Mem Inst Oswaldo Cruz
Capote-Morales R, Benito A, Berzosa P, González V, García L, Sastre-González A, Akindele AA, Ojurongbe O, Ta-Tang TH.   +8 more
europepmc   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source