Results 241 to 250 of about 982,945 (306)

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

open access: yesCell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu   +5 more
wiley   +1 more source

Raising the bar: genus-specific nested PCR improves detection and lineage identification of avian haemosporidian parasites. [PDF]

open access: yesFront Cell Infect Microbiol
Musa S   +6 more
europepmc   +1 more source

Importance of using genetic data to inform conservation captive breeding: A tale of two species of threatened macaws (Ara spp.)

open access: yesConservation Science and Practice, EarlyView.
Unmanaged captive populations of threatened species often harbor hidden genetic risks, so using genomic tools, we audited a large private macaw collection and uncovered extensive hybridization and high inbreeding. Our findings provide an actionable framework for how routine genetic screening can be used to mitigate these risks, manage captive breeding ...
George Olah   +4 more
wiley   +1 more source

Consensus‐based Guideline on tinea capitis

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The consensus‐based guideline developed under the auspices of the German Dermatological Society (DDG) is intended to provide physicians with a structured framework for clinical decision‐making in the management of patients with tinea capitis and to contribute to improved diagnostic accuracy, treatment adherence, and prevention. Tinea capitis is
Peter Mayser   +19 more
wiley   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

open access: yesEcological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda   +5 more
wiley   +1 more source

Post‐Hoc Long‐Read Sequencing Links Leukemic Mutation Status to Single‐Cell Transcriptomes

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Single‐cell RNA‐sequencing‐based characterization of cells that belong to the neoplastic clone is a major challenge in hematologic neoplasms, where malignant and normal cells coexist. Confident molecular profiling requires simultaneous analysis of gene expression and genetic mutations in individual cells, an ability that is not supported by ...
Sofia Papavasileiou   +8 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

open access: yesThe FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz   +13 more
wiley   +1 more source

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