In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review. [PDF]
PLoS ONE, 2017 BackgroundMultiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a ...
Tamara Hoppenbrouwers +10 more
doaj +2 more sources
Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia
Frontiers in Cell and Developmental Biology, 2023 Background: NETosis occurs in the context of infection or inflammation and results in the expulsion of decondensed DNA filaments called NETs (Neutrophil Extracellular Traps) into the extracellular environment.
Florence Guillotin +19 more
doaj +3 more sources
Phytochemicals as potential inhibitors of NETosis: implications for immunothrombosis and chronic disease management [PDF]
BMC Complementary Medicine and TherapiesBackground NETosis, a specialized form of neutrophil cell death, plays a dual role in immune regulation. While NET formation is essential for capturing pathogens, excessive NETosis contributes to immunothrombosis, oxidative stress, and tissue damage ...
Chen Juanlu +3 more
doaj +2 more sources
Molecular mechanisms and therapeutic target of NETosis in diseases
MedComm, 2022 Evidence shows that neutrophils can protect the host against pathogens in multiple ways, including the formation and release of neutrophil extracellular traps (NETs).
weiqi Hong
exaly +2 more sources
Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation [PDF]
Frontiers in Immunology, 2019 Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial ...
Hanna Bonnekoh +9 more
doaj +5 more sources
Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus
Современная ревматология, 2021 Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease.
K. S. Nurbaeva +2 more
doaj +1 more source
Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]
, 2016 Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E +19 more
core +6 more sources
Experimental Gerontology, 2023 Neutrophil extracellular trap formation (NETosis) is a mechanism used by neutrophils to capture pathogens with their own DNA. However, the exacerbation of this immune response is related to serious inflammatory diseases.
Nicolás Vidal-Seguel +12 more
doaj +1 more source
Frontiers in Immunology, 2023 Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis), and generated either by NADPH oxidases (e.g., during infections) or mitochondria (e.g., sterile injury) in neutrophils. We recently showed that ultraviolet (
Dhia Azzouz +4 more
doaj +1 more source
Histone Acetylation Promotes Neutrophil Extracellular Trap Formation
Biomolecules, 2019 Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J. Hamam +2 more
doaj +1 more source