Results 11 to 20 of about 18,973 (244)
Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis [PDF]
Frontiers in Medicine, 2018 Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellular pH
Meraj A. Khan +15 more
doaj +4 more sources
Heterotypic intercellular interactions as regulators of NETosis [PDF]
Frontiers in Immunology, 2016 Neutrophil extracellular traps (NETs) are chromatin-derived webs extruded from neutrophils in response to either infection or sterile stimulation with chemicals, cytokines, or microbial products.
Nayef M. Kazzaz +2 more
doaj +3 more sources
Autoimmune Diseases, 2013 Neutrophils are the first line of defense of the immune system against infection. Among their weaponry, they have the ability to mix and extrude their DNA and bactericidal molecules creating NET-like structures in a unique type of cell death called NETosis.
Mesa, Miguel Antonio, Vasquez, Gloria
+5 more sources
Cellular Mechanisms of NETosis [PDF]
Annual Review of Cell and Developmental Biology, 2020 Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with
Hawa Racine, Thiam +3 more
openaire +2 more sources
NETosis in Alzheimer’s Disease [PDF]
Frontiers in Immunology, 2017 Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses.
Pietronigro, Enrica Caterina +3 more
openaire +3 more sources
Receptor-Mediated NETosis on Neutrophils [PDF]
Frontiers in Immunology, 2021 Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates ...
Tao Chen +19 more
openaire +3 more sources
Untangling “NETosis” from NETs [PDF]
European Journal of Immunology, 2019 Abstract Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins.
Shida Yousefi +6 more
openaire +2 more sources
Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]
, 2017 NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina +8 more
core +1 more source
Frontiers in Immunology, 2018 Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis.
Ajantha Nadesalingam +5 more
doaj +1 more source
ROS and DNA repair in spontaneous versus agonist-induced NETosis: Context matters
Frontiers in Immunology, 2022 Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis). Nevertheless, how ROS induces NETosis at baseline and during neutrophil activation is unknown. Although neutrophils carry DNA transcription, replication and
Dhia Azzouz +4 more
doaj +1 more source