Results 11 to 20 of about 19,431 (234)
Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis [PDF]
Frontiers in Medicine, 2018 Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellular pH
Meraj A. Khan +15 more
doaj +4 more sources
Heterotypic intercellular interactions as regulators of NETosis [PDF]
Frontiers in Immunology, 2016 Neutrophil extracellular traps (NETs) are chromatin-derived webs extruded from neutrophils in response to either infection or sterile stimulation with chemicals, cytokines, or microbial products.
Nayef M. Kazzaz +2 more
doaj +3 more sources
Autoimmune Diseases, 2013 Neutrophils are the first line of defense of the immune system against infection. Among their weaponry, they have the ability to mix and extrude their DNA and bactericidal molecules creating NET-like structures in a unique type of cell death called NETosis.
Mesa, Miguel Antonio, Vasquez, Gloria
+5 more sources
Cellular Mechanisms of NETosis [PDF]
Annual Review of Cell and Developmental Biology, 2020 Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with
Hawa Racine, Thiam +3 more
openaire +2 more sources
NETosis in Alzheimer’s Disease [PDF]
Frontiers in Immunology, 2017 Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses.
Pietronigro, Enrica Caterina +3 more
openaire +3 more sources
Receptor-Mediated NETosis on Neutrophils [PDF]
Frontiers in Immunology, 2021 Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates ...
Tao Chen +19 more
openaire +3 more sources
Untangling “NETosis” from NETs [PDF]
European Journal of Immunology, 2019 Abstract Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins.
Shida Yousefi +6 more
openaire +2 more sources
Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]
, 2016 Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E +19 more
core +6 more sources
Experimental Gerontology, 2023 Neutrophil extracellular trap formation (NETosis) is a mechanism used by neutrophils to capture pathogens with their own DNA. However, the exacerbation of this immune response is related to serious inflammatory diseases.
Nicolás Vidal-Seguel +12 more
doaj +1 more source
Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Neutrophils are the most abundant type of white blood cells. Upon stimulation, they are able to decondense and release their chromatin as neutrophil extracellular traps (NETs). This process (NETosis) is part of immune defense mechanisms but also plays an
Luise Erpenbeck +12 more
doaj +1 more source