Results 31 to 40 of about 18,973 (244)

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis? [PDF]

, 2014
Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies ...
Gadjeva, Mihaela, Rahman, Samir
core   +1 more source

Influences of chloride and hypochlorite on neutrophil extracellular trap formation. [PDF]

PLoS ONE, 2012
The release by neutrophils of DNA-based extracellular traps (NETs) is a recently recognized innate immune phenomenon that contributes significantly to control of bacterial pathogens at tissue foci of infection.
Kathryn Akong-Moore, Ohn A Chow, Maren von Köckritz-Blickwede, Victor Nizet   +3 more
doaj   +1 more source

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Frontiers in Immunology, 2021
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4
Patrick Münzer, Patrick Münzer, Patrick Münzer, Patrick Münzer, Roberto Negro, Roberto Negro, Shoichi Fukui, Shoichi Fukui, Lucas di Meglio, Lucas di Meglio, Lucas di Meglio, Karen Aymonnier, Karen Aymonnier, Karen Aymonnier, Long Chu, Long Chu, Deya Cherpokova, Deya Cherpokova, Sarah Gutch, Sarah Gutch, Nicoletta Sorvillo, Nicoletta Sorvillo, Lai Shi, Lai Shi, Venkat Giri Magupalli, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Rüdiger E. Scharf, Rüdiger E. Scharf, Clare M. Waterman, Clare M. Waterman, Hao Wu, Hao Wu, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner   +37 more
doaj   +1 more source

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. [PDF]

, 2012
Antineutrophil cytoplasmic antibodies (ANCAs) target proteins normally retained within neutrophils, indicating that cell death is involved in the autoimmunity process. Still, ANCA pathogenesis remains obscure.
Abdgawad, Alcorta, Barbara Cappetti, Bennett, Bianchi, Brinkmann, Carla Guarnotta, Cassatella, Caterina Vitali, Chin, Claudia Chiodoni, Claudio Tripodo, Clayton, Colombo, Cristiana Guiducci, Di Carlo, Dittmar, Donnelly, Drenkard, Falk, Fuchs, Gaipl, Galeazzi, Garcia-Romo, Gilligan, Griffith, Guiducci, Jarius, Kantari, Kessenbrock, Lande, Manolova, Mariella Parenza, Mario P. Colombo, Martinelli, Metzler, Munafo, Nagata, Nathan, Patrizia Casalini, Patry, Potter, Pradhan, Remijsen, Sabina Sangaletti, Sangaletti, Santiago-Raber, Silvia Piconese, Specks, Spronk, Steinman, Tripodo, van der Geld, van Timmeren, Villanueva, Wernick, Witko-Sarsat, Ziegler-Heitbrock   +57 more
core   +1 more source

New Insight into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Frontiers in Immunology, 2016
Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred ...
Hang Yang, Mona Helena Biermann, Jan Markus Brauner, Yi Liu, Yi Zhao, Martin Herrmann   +5 more
doaj   +1 more source

Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning

Frontiers in Pharmacology, 2023
Background: Soft-tissue sarcomas (STSs) are a rare type of cancer, accounting for about 1% of all adult cancers. Treatments for STSs can be difficult to implement because of their diverse histological and molecular features, which lead to variations in ...
Lin Qi, Lin Qi, Fangyue Chen, Lu Wang, Lu Wang, Zhimin Yang, Zhimin Yang, Zhimin Yang, Wenchao Zhang, Wenchao Zhang, Zhihong Li, Zhihong Li   +11 more
doaj   +1 more source

Investigation the reasons for varying the severity of COVID-19 from person to person: A review study

Fiyz̤, 2022
Background: COVID-19 is caused by the SARS-COV-2 virus and mainly affects the lung tissue. In addition, other tissues are attacked by the virus. Reports have shown that clinical manifestations in Covid-19 patients vary from asymptomatic to acute ...
Mohsen Rahmani, Bahare Nikoozar , Mahboobeh Golchin, Marziyeh Tavalaee , Mehdi Hajian , Mohammad Hossein Nasr-Esfahani   +5 more
doaj  

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes [PDF]

, 2014
Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D.
Bornstein, SR, Lam, KSL, Tu, Y, Wang, Y, Xiao, Y, Xu, A, Ye, D, Zhang, J, Zhong, L, Zhou, Z   +9 more
core   +1 more source