Results 31 to 40 of about 19,431 (234)
Histone Acetylation Promotes Neutrophil Extracellular Trap Formation
Biomolecules, 2019 Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J. Hamam +2 more
doaj +1 more source
Diverse Roles of NETosis in the Pathogenesis of Lupus
Frontiers in Immunology, 2022 NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang +8 more
doaj +1 more source
Frontiers in Immunology, 2018 Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis.
Ajantha Nadesalingam +5 more
doaj +1 more source
ROS induces NETosis by oxidizing DNA and initiating DNA repair
Cell Death Discovery, 2021 Reactive oxygen species (ROS) are essential for neutrophil extracellular trap (NET) formation or NETosis. Nevertheless, how ROS induces NETosis is unknown. Neutrophil activation induces excess ROS production and a meaningless genome-wide transcription to
Dhia Azzouz +2 more
doaj +1 more source
What makes gouty inflammation so variable? [PDF]
, 2017 Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core +2 more sources
Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis? [PDF]
, 2014 Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies ...
Gadjeva, Mihaela, Rahman, Samir
core +1 more source
Investigation the reasons for varying the severity of COVID-19 from person to person: A review study
Fiyz̤, 2022 Background: COVID-19 is caused by the SARS-COV-2 virus and mainly affects the lung tissue. In addition, other tissues are attacked by the virus. Reports have shown that clinical manifestations in Covid-19 patients vary from asymptomatic to acute ...
Mohsen Rahmani +5 more
doaj
Influences of chloride and hypochlorite on neutrophil extracellular trap formation. [PDF]
PLoS ONE, 2012 The release by neutrophils of DNA-based extracellular traps (NETs) is a recently recognized innate immune phenomenon that contributes significantly to control of bacterial pathogens at tissue foci of infection.
Kathryn Akong-Moore +3 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
New Insight into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation
Frontiers in Immunology, 2016 Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred ...
Hang Yang +5 more
doaj +1 more source