Results 41 to 50 of about 19,431 (234)

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes [PDF]

, 2014
Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D.
Bornstein, SR, Lam, KSL, Tu, Y, Wang, Y, Xiao, Y, Xu, A, Ye, D, Zhang, J, Zhong, L, Zhou, Z   +9 more
core   +1 more source

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. [PDF]

, 2012
Antineutrophil cytoplasmic antibodies (ANCAs) target proteins normally retained within neutrophils, indicating that cell death is involved in the autoimmunity process. Still, ANCA pathogenesis remains obscure.
Abdgawad, Alcorta, Barbara Cappetti, Bennett, Bianchi, Brinkmann, Carla Guarnotta, Cassatella, Caterina Vitali, Chin, Claudia Chiodoni, Claudio Tripodo, Clayton, Colombo, Cristiana Guiducci, Di Carlo, Dittmar, Donnelly, Drenkard, Falk, Fuchs, Gaipl, Galeazzi, Garcia-Romo, Gilligan, Griffith, Guiducci, Jarius, Kantari, Kessenbrock, Lande, Manolova, Mariella Parenza, Mario P. Colombo, Martinelli, Metzler, Munafo, Nagata, Nathan, Patrizia Casalini, Patry, Potter, Pradhan, Remijsen, Sabina Sangaletti, Sangaletti, Santiago-Raber, Silvia Piconese, Specks, Spronk, Steinman, Tripodo, van der Geld, van Timmeren, Villanueva, Wernick, Witko-Sarsat, Ziegler-Heitbrock   +57 more
core   +1 more source

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Frontiers in Immunology, 2021
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4
Patrick Münzer, Patrick Münzer, Patrick Münzer, Patrick Münzer, Roberto Negro, Roberto Negro, Shoichi Fukui, Shoichi Fukui, Lucas di Meglio, Lucas di Meglio, Lucas di Meglio, Karen Aymonnier, Karen Aymonnier, Karen Aymonnier, Long Chu, Long Chu, Deya Cherpokova, Deya Cherpokova, Sarah Gutch, Sarah Gutch, Nicoletta Sorvillo, Nicoletta Sorvillo, Lai Shi, Lai Shi, Venkat Giri Magupalli, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Rüdiger E. Scharf, Rüdiger E. Scharf, Clare M. Waterman, Clare M. Waterman, Hao Wu, Hao Wu, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner   +37 more
doaj   +1 more source

Neutrophil extracellular traps (NETs) : formation and implications [PDF]

, 2013
Neutrophils are cells of the immune system which freely circulate in blood vessels and are recruited to the inflammation sites when the human organism responds to microbial infections.
Rąpała-Kozik, Maria, Zawrotniak, Marcin   +1 more
core   +1 more source

Functional Verification and Prognostic Value of Neutrophil Extracellular Trap-Related Genes in Pancreatic Cancer Progression

Frontiers in Bioscience-Landmark
Background: Pancreatic carcinoma (PC), a severely malignant neoplasm of the digestive system, is characterized by an unfavorable prognosis.
Jiaxin Xu, Liying Tu, Lijing Ma, Qisheng Tang, Yu Cao, Lihong Jiang   +5 more
doaj   +1 more source

Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils

Biomolecules, 2018
Various biomolecules induce neutrophil extracellular trap (NET) formation or NETosis. However, the effect of fatty acids on NETosis has not been clearly established. In this study, we focused on the NETosis-inducing ability of several lipid molecules. We
Meraj A. Khan, Cecil Pace-Asciak, Jassim M. Al-Hassan, Mohammad Afzal, Yuan Fang Liu, Sosamma Oommen, Bincy M. Paul, Divya Nair, Nades Palaniyar   +8 more
doaj   +1 more source

Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning

Frontiers in Pharmacology, 2023
Background: Soft-tissue sarcomas (STSs) are a rare type of cancer, accounting for about 1% of all adult cancers. Treatments for STSs can be difficult to implement because of their diverse histological and molecular features, which lead to variations in ...
Lin Qi, Lin Qi, Fangyue Chen, Lu Wang, Lu Wang, Zhimin Yang, Zhimin Yang, Zhimin Yang, Wenchao Zhang, Wenchao Zhang, Zhihong Li, Zhihong Li   +11 more
doaj   +1 more source

Anti-carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus [PDF]

, 2018
Background: The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to identify patients developing the ...
Alessandri, Cristiano, Ceccarelli, Fulvia, Cipriano, Enrica, Colasanti, Tania, Conti, Fabrizio, Mancini, Riccardo, Massaro, Laura, Natalucci, Francesco, Pendolino, Monica, Perricone, Carlo, Spinelli, Francesca Romana, Valesini, Guido   +11 more
core   +1 more source

neutrophils are on the payroll [PDF]

, 2015
Viral hemorrhagic fever caused by hantaviruses is an emerging infectious disease for which suitable treatments are not available. In order to improve this situation a better understanding of hantaviral pathogenesis is urgently required.
Krüger, Detlev H., Raftery, Martin J., Schönrich, Günther   +2 more
core   +1 more source

NETosis occurs independently of neutrophil serine proteases [PDF]

Journal of Biological Chemistry, 2020
Neutrophils are primary host innate immune cells defending against pathogens. One proposed mechanism by which neutrophils prevent the spread of pathogens is NETosis, the extrusion of cellular DNA resulting in neutrophil extracellular traps (NETs). The protease neutrophil elastase (NE) has been implicated in the formation of NETs through proteolysis of ...
Paulina Kasperkiewicz, Anne Hempel, Tomasz Janiszewski, Sonia Kołt, Scott J. Snipas, Marcin Drag, Guy S. Salvesen   +6 more
openaire   +2 more sources