Results 51 to 60 of about 18,973 (244)

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Investigating neutrophil cell death in TB pathogenesis [version 2; peer review: 2 approved]

Gates Open Research, 2022
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs).
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Thumbi Ndung'u, Duran Ramsuran, Mohlopheni J Marakalala, Denelle Moodley, Kimone L Fisher   +6 more
doaj   +1 more source

Interleukin-9 over-expression and T helper 9 polarization in systemic sclerosis patients. [PDF]

, 2017
T helper 9 (Th9) cells and interleukin (IL)-9 are involved in the pathogenesis of several autoimmune diseases. The exact role of IL-9 and Th9 cells in patients with systemic sclerosis (SSc) have not yet been studied adequately. IL-9, IL-9R, transcription
Candore, G., Ciccia, F., Cipriani, P., Di Liberto, D., Dieli, F., Gambino, C., Giacomelli, R., Guggino, G., Lo Pizzo, M., Rizzo, A., Ruscitti, P., Sireci, G., Triolo, G.   +12 more
core   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Frontiers in Immunology, 2018
Staphylococcus aureus are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in S. aureus-induced NETosis. We determined the Protein A production of
Tamara Hoppenbrouwers, Tamara Hoppenbrouwers, Andi R. Sultan, Tsion E. Abraham, Nicole A. Lemmens-den Toom, Silvie Hansenová Maňásková, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willem J. B. van Wamel, Moniek P. M. de Maat, Johan W. van Neck   +10 more
doaj   +1 more source

Low NETosis Induced in Anaplasma phagocytophilum-Infected Cells

Vaccines, 2022
Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells. In this study, bioinformatics analysis was conducted to further characterize A.
Sara Artigas-Jerónimo, Almudena González-García, José de la Fuente, Valeria Blanda, Mojtaba Shekarkar Azgomi, Margarita Villar, Leila Mohammadnezhad, Francesca Grippi, Alessandra Torina, Guido Sireci   +9 more
openaire   +6 more sources

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Human neutrophils phagocytose and kill Acinetobacter baumanii and A. pittii [PDF]

, 2017
Acinetobacter baumannii is a common cause of health care associated infections worldwide. A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections other than those from A. baumannii.
AA Ocampo-Sosa, AJ Standish, B Guo, BG Surewaard, C Greene, DB Kuhns, G Kamoshida, G Kamoshida, H Faassen van, H Kress, H Rosen, J Mestas, J Ramos-Vivas, JM Breslow, JM Voyich, LC Antunes, M Greenlee-Wacker, M Lazaro-Diez, M Pagano, M Yamamoto, MB Johnson, MM Mircescu, MS Bhuiyan, MT Silva, NM Clark, O Chertov, P Espinal, P Nordenfelt, PH Naccache, R Menegazzi, SD Kobayashi, SH Kaufmann, T Konstantinidis, T Lahmer, T Lu, TA Fuchs, V Brinkmann, V Kumar, W Kamolvit, X Vila-Farres   +39 more
core   +2 more sources

Machine Learning to Quantitate Neutrophil NETosis [PDF]

Scientific Reports, 2019
AbstractWe introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate neutrophil NETosis, a recently discovered process involved in multiple human diseases.
Elsherif, Laila, Sciaky, Noah, Metts, Carrington A., Modasshir, Md., Rekleitis, Ioannis, Burris, Christine A., Walker, Joshua A., Ramadan, Nadeem, Leisner, Tina M., Holly, Stephen P., Cowles, Martis W., Ataga, Kenneth I., Cooper, Joshua N., Parise, Leslie V.   +13 more
openaire   +3 more sources

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source