Results 51 to 60 of about 19,431 (234)

2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation

Journal of Lipid Research, 2018
Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of granule and nuclear contents, which are then released in the extracellular space ...
ElisaN.D. Palladino, Lalage A. Katunga, Grant R. Kolar, David A. Ford   +3 more
doaj   +1 more source

Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy [PDF]

, 2016
Oxygen deprivation and infection are major causes of perinatal brain injury leading to cerebral palsy and other neurological disabilities. The identification of novel key factors mediating white and grey matter damage are crucial to allow better ...
Adhami, Alonso-Alconada, Azad, Baburamani, Balandraud, Balduini, Block, Bozdag, Brinkmann, Brown, Byrd, Chavanas, Chavanas, Cherian, Cherrington, Choi, Christophorou, Cotten, Cui, Culman, David, Dingley, Dixon, Douglas-Escobar, Dragunow, Dwivedi, Erny, Fan, Faulkner, Ferretti, Ferriero, Fox, Fricker, Garcia-Romo, Ginet, Goyal, Guerrin, Gupta, Gupta, György, Hagberg, Hagberg, Hagiwara, Horibata, Imm, Ireland, Ireland, Karlsson, Kearney, Keilhoff, Kendall, Kendall, Kessenbrock, Keunen, Kholia, Knuckley, Kopatz, Kumral, Kurinczuk, Lande, Lange, Lange, Latuga, Law, Lee, Li, Li, Li, Loos, Loos, Luo, Ma, Mallard, Mallard, Marcos, Mari, Martin, Mastronardi, McCormack, Mirza, Moelants, Moelants, Musse, Neeli, Neeli, Neher, Neher, Neniskyte, Neumann, Northington, Perlman, Pirianov, Prempunpong, Proost, Robertson, Robertson, Rocha-Ferreira, Romano-Keeler, Romero, Sharda, Sherman, Simak, Slack, Spengler, Stenberg, Stys, Subramanian, Trabocchi, U, Uria-Avellanal, Villanueva, Vossenaar, Wang, Wang, Wassink, Wei, Witalison, Wood, Wright, Wu, Wu, Wyatt, Wyatt, Yektaei-Karin, Yi, Yost, Zhu, Zhu, Zhu, Zhu, Zipfel   +130 more
core   +2 more sources

The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae [PDF]

, 2017
Neutrophils play an important role in the innate immune response to infection with Streptococcus pneumoniae, the pneumococcus. Pneumococci are phagocytosed by neutrophils and undergo killing after ingestion.
Evans, Tom J., Ritchie, Neil D., Ullah, Ihsan   +2 more
core   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Frontiers in Immunology, 2018
Staphylococcus aureus are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in S. aureus-induced NETosis. We determined the Protein A production of
Tamara Hoppenbrouwers, Tamara Hoppenbrouwers, Andi R. Sultan, Tsion E. Abraham, Nicole A. Lemmens-den Toom, Silvie Hansenová Maňásková, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willem J. B. van Wamel, Moniek P. M. de Maat, Johan W. van Neck   +10 more
doaj   +1 more source

Interleukin-9 over-expression and T helper 9 polarization in systemic sclerosis patients. [PDF]

, 2017
T helper 9 (Th9) cells and interleukin (IL)-9 are involved in the pathogenesis of several autoimmune diseases. The exact role of IL-9 and Th9 cells in patients with systemic sclerosis (SSc) have not yet been studied adequately. IL-9, IL-9R, transcription
Candore, G., Ciccia, F., Cipriani, P., Di Liberto, D., Dieli, F., Gambino, C., Giacomelli, R., Guggino, G., Lo Pizzo, M., Rizzo, A., Ruscitti, P., Sireci, G., Triolo, G.   +12 more
core   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis

Efficacy and Mechanism Evaluation
Background Thrombosis with thrombocytopenia syndrome is a rare condition known to occur spontaneously or after heparin use. With the advent of COVID-19 vaccines during the pandemic, thrombosis with thrombocytopenia syndrome cases emerged post ...
Phillip LR Nicolson, Simon T Abrams, Gayatri Amirthalingam, Kevin Brown, Richard J Buka, Mark J Caulfield, Joshua Gardner, David Goldblatt, Charlotte Lovatt, Samantha J Montague, Dean J Naisbitt, Alan Parker, Sue Pavord, Mary E Ramsay, Jonathan AC Sterne, Cathie LM Sudlow, Cheng Hock Toh, Steve P Watson, Guozheng Wang, Angela M Wood, William Whiteley, Munir Pirmohamed   +21 more
doaj   +1 more source

Investigating neutrophil cell death in TB pathogenesis [version 1; peer review: 2 approved]

Gates Open Research, 2021
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs).
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Thumbi Ndung'u, Duran Ramsuran, Mohlopheni J Marakalala, Denelle Moodley, Kimone L Fisher   +6 more
doaj   +1 more source

Neutrophil extracellular traps as innate immune reaction against the emerging apicomplexan parasite Besnoitia besnoiti [PDF]

, 2014
Besnoitia besnoiti infection in cattle is an important emerging protozoan disease in Europe causing economic losses and severe clinical signs, such as generalized dermatitis, orchitis, and vulvitis in affected animals. Neutrophil extracellular trap (NET)
Cortes, Helder, Hermosilla, Carlos, Muñoz Caro, Tamara, Silva, Liliana M. R., Taubert, Anja   +4 more
core   +2 more sources