Results 61 to 70 of about 19,431 (234)
Low NETosis Induced in Anaplasma phagocytophilum-Infected Cells
Vaccines, 2022 Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells. In this study, bioinformatics analysis was conducted to further characterize A.
Sara Artigas-Jerónimo +9 more
openaire +6 more sources
Advanced Science, EarlyView.The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher +15 more
wiley +1 more source
Frontiers in Immunology, 2023 IntroductionHigh-grade serous ovarian cancer (HGSOC) is the second most frequent gynecological malignancy but the most lethal, partially due to the spread of the disease through the peritoneal cavity. Recent evidence has shown that, apart from their role
Sarai Tomás-Pérez +27 more
doaj +1 more source
Machine Learning to Quantitate Neutrophil NETosis [PDF]
Scientific Reports, 2019 AbstractWe introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate neutrophil NETosis, a recently discovered process involved in multiple human diseases.
Elsherif, Laila +13 more
openaire +3 more sources
Advanced Science, EarlyView.A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li +12 more
wiley +1 more source
Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis [PDF]
, 2016 The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in
Edwards, SW +7 more
core +3 more sources
Advanced Science, EarlyView.A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi +6 more
wiley +1 more source
Frontiers in Immunology, 2016 NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE).
Maximilian Ferdinand Konig +1 more
doaj +1 more source
Investigating neutrophil cell death in TB pathogenesis [version 2; peer review: 2 approved]
Gates Open Research, 2022 Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs).
Thabo Mpotje +6 more
doaj +1 more source
Terapevticheskii arkhivAim. To evaluate the levels of MPO-DNA complex in patients with systemic lupus erythematosus (SLE) and its association with the presence of lupus nephritis (LN). Materials and methods. The study included 77 patients with SLE, of whom 30 had SLE without anti phospholipid syndrome (APS), 47 had SLE with APS, and 20 were healthy individuals serving as ...
Tatiana M. Reshetnyak +6 more
openaire +3 more sources