Results 71 to 80 of about 49,281,268 (309)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Optimizing built-in pseudo-random self-testing for network-on-chip switches
, 2012 Most BIST architectures use pseudo-random test pattern generators. However, whenever this technique has been applied to on-chip interconnection networks, overly large testing latencies have been reported.
STRANO, Alessandro +4 more
core +1 more source
A Manycore Vision Processor for Real-Time Smart Cameras
Sensors, 2021 Real-time image processing and computer vision systems are now in the mainstream of technologies enabling applications for cyber-physical systems, Internet of Things, augmented reality, and Industry 4.0.
Bruno A. da Silva +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Adaptable Switch boxes as on-chip routing nodes for networks-on-chip
, 2005 Eickhoff R, Niemann J-C, Porrmann M, Rückert U. Adaptable Switch boxes as on-chip routing nodes for networks-on-chip. In: Rettberg A, Zanella MC, Rammig FJ, eds. From Specification to Embedded Systems Application .
Eickhoff, Ralf +6 more
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Reconfigurable Network-on-Chip for 3D Neural Network Accelerators
, 2018 Parallel hardware accelerators for large-scale neural networks typically consist of several processing nodes, arranged as a multi- or many-core system-on-chip, connected by a network-on-chip (NoC).
Firuzan, A., +3 more
core +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Agent-based on-chip network using efficient selection method
, 2011 Congestion in on-chip networks may cause many drawbacks in multiprocessor systems including throughput reduction, increase in latency, and additional power consumption.
Pasi Liljeberg +9 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source