Results 51 to 60 of about 132,420 (284)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Thermal/performance trade-off in network-on-chip architectures [PDF]

, 2012
Multi-core architectures are a promising paradigm to exploit the huge integration density reached by high-performance systems. Indeed, integration density and technology scaling are causing undesirable operating temperatures, having net impact on reduced
Corbetta, Simone, Fornaciari, William, Zoni, Davide   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Worst-Case Communication Time Analysis for On-Chip Networks With Finite Buffers

IEEE Access, 2023
Network-on-Chip (NoC) is the ideal interconnection architecture for many-core systems due to its superior scalability and performance. An NoC must deliver critical messages from a real-time application within specific deadlines.
Rubens Vicente De Liz Bomer, Cesar Albenes Zeferino, Laio Oriel Seman, Valderi Reis Quietinho Leithardt   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

HyPPI NoC: Bringing Hybrid Plasmonics to an Opto-Electronic Network-on-Chip

, 2017
As we move towards an era of hundreds of cores, the research community has witnessed the emergence of opto-electronic network on-chip designs based on nanophotonics, in order to achieve higher network throughput, lower latencies, and lower dynamic power.
El-Ghazawi, Tarek, Mehrabian, Armin, Narayana, Vikram K., Sorger, Volker J., Sun, Shuai   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Energy-aware Application Mapping onto 3D Mesh-Based Network-on-Chip using Heuristic Mapping Algorithms [PDF]

Journal of Universal Computer Science
Network-on-chip (NoC) architectures have emerged as a potential solution for facilitating communication between processing elements (PEs) in modern multi-core systems.
Kiran K A, Jaison Jacob
doaj   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hardware-Software Complex for Network-on-Chip Prototyping Using Multiple FPGAs

IEEE Access
This paper presents a hardware-software multi-FPGA complex designed for hardware prototyping of networks-on-chip (NoCs). The rationale for the use of multiple FPGAs for NoC prototyping is given.
Mikhail Y. Romashikhin, Aleksandr Y. Romanov   +1 more
doaj   +1 more source