Results 161 to 170 of about 3,321 (184)

Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma [PDF]

Biochemical and Biophysical Research Communications, 2023
Cutaneous melanoma is one of the most aggressive and deadly types of skin cancer and rates of disease are continuing to increase worldwide. Currently, no serum biomarkers exist for the early detection of cutaneous melanoma. Normal human cells cannot make
Christopher Day, James Paton, Michael P Jennings   +2 more
exaly   +5 more sources

Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome [PDF]

Xenotransplantation, 2019
International audienceHumans cannot synthesizeN-glycolylneuraminic acid (Neu5Gc) but dietary Neu5Gc can be absorbed and deposited on endothelial cells (ECs) and diet-induced anti-Neu5Gc antibodies (Abs) develop early in human life.
Beatrice Charreau, Cristina Costa, Jean-Paul Soulillou   +2 more
exaly   +2 more sources

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Preparation of lauryl thioglycoside of N-glycolylneuraminic acid (Neu5Gc) as a useful glycosyl donor for assembly of an oligosaccharide containing Neu5Gc

Tetrahedron Letters, 2021
Abstract Efficient synthesis of lauryl thioglycoside of Neu5Gc was accomplished from a known thioglycoside of Neu5Ac. The reactivities of the Neu5Gc thioglycoside for O-glycosidation by means of TMSOTf-NIS as a promoter system were investigated, and the thioglycoside showed good activities with simple alcohols. In addition to the simple alcohols, the
Jianhong Zhang, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano, Koji Matsuoka   +4 more
openaire   +1 more source

GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

Seminars in Oncology, 2018
Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the outer side of the plasma membrane of vertebrate cells.
Luis E Fernández, Ana M Vazquez
exaly   +3 more sources

Immune disguise: the mechanisms of Neu5Gc inducing autoimmune and transplant rejection

Genes & Immunity, 2022
Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc (N-hydroxyacetylneuraminic acid) is a pathogenic non-human sialic acid, which is very similar to the molecular structure of Neu5Ac (N-acetylneuraminic acid) in human body.
Fadian Ding, Yunfeng Lin, Guozhong Liu, Yuxin Liu, Feng Gao, Qicai Liu, Zhibo Zhang, Shangeng Weng   +7 more
openaire   +2 more sources

Specific Detection of Neu5Gc in Animal Tissues by Immunohistochemistry

2020
One of the major obstacles in xenotransplantation is tissue expression of the non-human mammalian carbohydrate N-glycolylneuraminic acid (Neu5Gc). This 9-carbon backbone acidic sugar is the hydroxylated form of N-acetylneuraminic acid (Neu5Ac), and both constitute the two most common sialic acid types in mammals. Loss of CMP-Neu5Ac hydroxylase encoding
Anu, Paul, Shirley, Bachar Abramovitch, Vered, Padler-Karavani   +2 more
openaire   +2 more sources

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

Glycobiology, 2008
Human heterophile antibodies that agglutinate animal erythrocytes are known to detect the nonhuman sialic acid N -glycolylneuraminic acid (Neu5Gc). This monosaccharide cannot by itself fill the binding site (paratope) of an antibody and can also be ...
Nissi Varki, Ajit Varki, Xi Chen
exaly   +2 more sources

Incorporation of the Non-Human Sialic Acid Neu5Gc into Human Leukemic Cells and Targeting by Natural Human Anti-Neu5Gc Antibodies.

Blood, 2004
Abstract Humans are incapable of synthesizing the common mammalian cell surface sialic acid N-glycolylneuraminic acid (Neu5Gc), due to an irreversible genetic mutation that occurred after our last common ancestor with great apes. Despite this, we found trace levels of Neu5Gc in certain normal human tissues, and higher levels in fetal and
Dzung H. Nguyen, Pam Tangvoranuntakul, Ajit Varki   +2 more
openaire   +1 more source

Neu5Gc (N-Glycolylneuraminic Acid)

2020
Among a group of SAs, NeuAc and NeuGc are two of the most common derivatives. SA biosynthesis begins at the cytosol and the synthesized SA is converted to activated nucleotide saccharide form in the nucleus. The activated SA is delivered to Golgi apparatus for ST reaction. STs add SA residues to the terminal sugars of the glycolipids, especially of the
openaire   +1 more source

Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation

Genes & Immunity
Repeated implantation failure (RIF) is one of the most prominent problems in the field of assisted reproduction. Neu5Gc on the surface of decidual macrophages (dMΦ) leads to different activation patterns of dMΦ, which affects embryo implantation and development.
Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai   +5 more
openaire   +2 more sources