Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D+5 more
core +2 more sources
The bed nuclei of the stria terminalis (BST) are critically important for integrating stress-related signals between the limbic forebrain and hypothalamo-pituitary-adrenal (HPA) effector neurons in the paraventricular hypothalamus (PVH).
S. Johnson+7 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
FRACTIONAL ANISOTROPY IN DEGENERATIVE CERVICAL STENOSIS SURGERY PROGNOSTIC: A SYSTEMATIC REVIEW [PDF]
Cervical spondylotic myelopathy (CSM) is a common disease with an increased anticipated burden to health systems worldwide. Methods to predict outcomes in these patients are needed so physicians can provide more effective care. Fractional anisotropy (FA)
Leon Cleres Penido Pinheiro+3 more
doaj +1 more source
Adaptive Reorganization of Neural Pathways for Continual Learning with Spiking Neural Networks [PDF]
The human brain can self-organize rich and diverse sparse neural pathways to incrementally master hundreds of cognitive tasks. However, most existing continual learning algorithms for deep artificial and spiking neural networks are unable to adequately auto-regulate the limited resources in the network, which leads to performance drop along with energy
arxiv
A feedback model of visual attention [PDF]
Feedback connections are a prominent feature of cortical anatomy and are likely to have significant functional role in neural information processing. We present a neural network model of cortical feedback that successfully simulates neurophysiological ...
Johnson, M H, Spratling, M W
core +2 more sources
Anatomical organization and neural pathways of the ovarian plexus nerve in rats
BackgroundIn this work, a detailed anatomical description of the ovarian plexus nerve (OPN) in rats is presented. The distribution of the OPN was analyzed by gross anatomy; the features of the superior mesenteric ganglion (SMG) were determined by ...
C. Pastelín+5 more
semanticscholar +1 more source
Vestibular Pharmacology and Neural Pathway
This paper deals with recent advances in anatomical, biochemical, pharmacological and physiological studies on the vestibular system. Fiber connections and characteristics of the vestibular neurons and primary vestibular neurons were discussed in relation to other structures such as the cerebellum, oculomotor nuclei, reticular formation, and spinal ...
Haruo Takahashi+4 more
openaire +3 more sources
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak+14 more
wiley +1 more source