Patterned and Functionalized Nanofiber Scaffolds in Three-Dimensional Hydrogel Constructs Enhance Neurite Outgrowth and Directional Control [PDF]
J Neural Eng. 2014 Dec;11(6):066009, 2015 Neural tissue engineering holds incredible potential to restore functional capabilities to damaged neural tissue. It was hypothesized that patterned and functionalized nanofiber scaffolds could control neurite direction and enhance neurite outgrowth. Aligned nanofibers were created according to a mathematical model and were shown to enable significant ...
arxiv +1 more source
Extracellular vesicles, ageing, and therapeutic interventions [PDF]
, 2018 A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals.
Neytchev, Ognian +3 more
core +1 more source
Brain and BehaviorBackground The association between gut microbiota (GM) and Parkinson's disease (PD) has been well established, but whether there is a causal relationship between the two and whether inflammatory cytokines (ICs) act as mediators remain unclear.
Ma Caiyun +5 more
doaj +1 more source
BMC Neuroscience, 2021 This article has been retracted.
Sabine Wislet-Gendebien +8 more
doaj +1 more source
Optimal Management of Naturally Regenerating Uneven-aged Forests [PDF]
, 2016 A shift from even-aged forest management to uneven-aged management practices leads to a problem rather different from the existing straightforward practice that follows a rotation cycle of artificial regeneration, thinning of inferior trees and a clearcut.
arxiv +1 more source
Noise-Robust Dense Retrieval via Contrastive Alignment Post Training [PDF]
arXiv, 2023 The success of contextual word representations and advances in neural information retrieval have made dense vector-based retrieval a standard approach for passage and document ranking. While effective and efficient, dual-encoders are brittle to variations in query distributions and noisy queries.
arxiv
Using Crosslinked Hyaluronic Acid (HA) and Collagen Scaffolds with Sustained Brain-Derived Neurotrophic Factor (BDNF) Release for Post-SCI Nerve Regeneration [PDF]
, 2018 Traumatic events resulting in spinal cord injuries (SCIs) often leave people paralyzed or with partial loss of motor function. The physical disabilities arising from traumatic events prevent people from functioning at the same level as pre-injury.
Doshi, Panth
core +1 more source
Cortical AAV-CNTF gene therapy combined with intraspinal mesenchymal precursor cell transplantation promotes functional and morphological outcomes after spinal cord injury in adult rats [PDF]
, 2018 Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the ...
Akinpelu, Emmanuel A +14 more
core +3 more sources
Cell Reports, 2019 Summary: Under food deprivation conditions, Drosophila larvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs).
Keisuke Kamimura +4 more
doaj
Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model
Neural Plasticity, 2013 The aim of the present study is to detect a combination method to utilize gene therapy for the treatment of Parkinson’s disease (PD). Here, a PD rat model is used for the in vivo gene therapy of a recombinant adeno-associated virus (AAV2) containing a ...
Deyu Zheng +5 more
doaj +1 more source